三碘甲状腺原氨酸
三碘甲状腺原氨酸用途
三碘甲状腺原氨酸名称
[ CAS 号 ]:
6893-02-3
[ 中文名 ]:
三碘甲状腺原氨酸
[ 英文名 ]:
liothyronine
[中文别名 ]:
[英文别名 ]:
- 3,3',5 TRIIODOTHYRONINE (T3), IRMM STANDARD
- 3,5,3′-tri-iodo-l-thyronine
- Liothyronine (T3)
- O-(4-Hydroxy-3-iodophenyl)-3,5-diiodotyrosine
- L-TYROSINE,O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-
- L T3
- Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-
- O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
- 3,3',5-Triiodothyronine
- Triiodothyronine
三碘甲状腺原氨酸生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[体外研究]
[细胞实验]
[参考文献]
[相关活性小分子]
三碘甲状腺原氨酸物理化学性质
[ 密度 ]:
2.4±0.1 g/cm3
[ 沸点 ]:
563.5±50.0 °C at 760 mmHg
[ 熔点 ]:
234-238 °C(lit.)
[ 分子式 ]:
C15H12I3NO4
[ 分子量 ]:
650.974
[ 闪点 ]:
294.6±30.1 °C
[ 精确质量 ]:
650.790039
[ PSA ]:
92.78000
[ LogP ]:
5.08
[ 外观性状 ]:
粉末
[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C
[ 折射率 ]:
1.763
[ 储存条件 ]:
避免光
三碘甲状腺原氨酸MSDS
三碘甲状腺原氨酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY6750000
- CHEMICAL NAME :
- Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, L-
- CAS REGISTRY NUMBER :
- 6893-02-3
- BEILSTEIN REFERENCE NO. :
- 2710227
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C15-H12-I3-N-O4
- MOLECULAR WEIGHT :
- 650.98
- WISWESSER LINE NOTATION :
- QVYZ1R CI EI DOR DQ CI
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 32,197,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 ug/kg/30D-I
- TOXIC EFFECTS :
- Cardiac - other changes Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 52,89,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 ug/kg/3D-I
- TOXIC EFFECTS :
- Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 84,149,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 ug/kg/6D-I
- TOXIC EFFECTS :
- Endocrine - evidence of thyroid hyperfunction Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3 Volume(issue)/page/year: 13(2),41,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 16500 ug/kg/30D-I
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 52,89,1988 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1400 ug/kg
- SEX/DURATION :
- female 16-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- HMMRA2 Hormone and Metabolic Research. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1969- Volume(issue)/page/year: 10,425,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 300 ug/kg
- SEX/DURATION :
- female 19-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 12,162,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 75 ug/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,529,1974
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 480 ug/kg
- SEX/DURATION :
- female 10-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 84,115,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 900 ug/kg
- SEX/DURATION :
- female 11-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),65A,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 250 ug/kg
- SEX/DURATION :
- female 25-26 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 9,115,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 300 ug/kg
- SEX/DURATION :
- female 30 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Endocrine - changes in growth hormone
- REFERENCE :
- THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 28,205,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9726 No. of Facilities: 219 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2518 (estimated) No. of Female Employees: 1886 (estimated)
三碘甲状腺原氨酸安全信息
[ 符号 ]:
GHS02, GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H225-H301 + H311 + H331-H370
[ 警示性声明 ]:
P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi:Irritant;
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
S36-S26
[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution
[ WGK德国 ]:
3
[ RTECS号 ]:
AY6750000
[ 海关编码 ]:
2922509090
三碘甲状腺原氨酸合成路线
三碘甲状腺原氨酸上下游产品
三碘甲状腺原氨酸上游产品
三碘甲状腺原氨酸下游产品
三碘甲状腺原氨酸海关
[ 海关编码 ]: 2922509090
[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单
[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
三碘甲状腺原氨酸文献
Chem. Res. Toxicol. 23 , 171-83, (2010)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
Developing structure-activity relationships for the prediction of hepatotoxicity.Chem. Res. Toxicol. 23 , 1215-22, (2010)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...
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产品详情:3,3'',5-三碘-L-甲腺原氨酸
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¥549.0/25mg
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¥需询单/1g
¥需询单/1g
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产品详情:Triiodothyronine
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¥351.9/1g
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产品详情:3,3',5-三碘-L-甲腺原氨酸
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联系人:夏言
产品详情:[Perfemiker]3,3',5-三碘-L-甲腺原氨酸,≥95%
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相关化合物
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标题:三碘甲状腺原氨酸_MSDS_用途_密度_CAS号【6893-02-3】_化源网 地址:https://www.chemsrc.com/amp/cas/6893-02-3_835557.html