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氨苄西林钠

氨苄西林钠用途

Ampicillin sodium是一种广谱β-内酰胺类抗生素,可对抗多种革兰氏阳性和革兰氏阴性细菌 (bacteria)。

氨苄西林钠名称

[ CAS 号 ]:
69-52-3

[ 中文名 ]:
氨苄青霉素钠

[ 英文名 ]:
Ampicillin sodium

[中文别名 ]:

[英文别名 ]:

氨苄西林钠生物活性

[ 描述 ]:

Ampicillin sodium是一种广谱β-内酰胺类抗生素,可对抗多种革兰氏阳性和革兰氏阴性细菌 (bacteria)。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染

[ 靶点 ]

Bacterial[1]


[体外研究]

氨苄青霉素以剂量依赖性方式抑制猪源大肠杆菌的生长。氨苄青霉素的有效抑制浓度为2.5 uG/mL [1]。

[体内研究]

氨苄西林在减轻11周龄猪出血性肠炎的症状方面非常有效[1]。氨苄西林在胆汁中产生的最大浓度是血清中的两倍。口服给药后氨苄西林的峰值浓度是门静脉血液中的两倍,高于外周血[2]。氨苄西林提供针对缺血再灌注脑损伤的神经保护作用。氨苄青霉素降低MMP的活性并增加GLT-1的表达水平。氨苄青霉素预处理可显着降低全脑前脑缺血后内侧海马细胞死亡[3]。

[动物实验]

小鼠:将氨苄青霉素溶于生理盐水中。用氟烷麻醉雄性C57BL / 6小鼠,并进行双侧颈总动脉闭塞40分钟。在短暂的前脑缺血之前,每天施用氨苄青霉素(200mg / kg,腹膜内[ip])或青霉素G(6,000U / kg或20,000U / kg,ip),持续5天。在对照动物中,以相同的体积和时间表给予盐水[3]。

[参考文献]

[1]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7.

[2]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5.

[3]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92.


[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 头孢噻肟钠

氨苄西林钠物理化学性质

[ 沸点 ]:
683.9ºC at 760 mmHg

[ 熔点 ]:
215 °C (dec.)(lit.)

[ 分子式 ]:
C16H18N3NaO4S

[ 分子量 ]:
371.387

[ 精确质量 ]:
371.091583

[ PSA ]:
140.86000

[ LogP ]:
0.01250

[ 外观性状 ]:
白色至灰白色固体

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, very faintly yellow

氨苄西林钠MSDS

氨苄西林钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH8400000
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)- 3,3-dimethyl-7-oxo-, sodium salt, D-(-)-
CAS REGISTRY NUMBER :
69-52-3
LAST UPDATED :
199510
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C16-H18-N3-O4-S.Na
MOLECULAR WEIGHT :
371.42
WISWESSER LINE NOTATION :
T45 ANV ESTJ CMVYZR& F1 F1 GVQ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
100 mg/kg/5D
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,707,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,356,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,356,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,356,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5314 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,356,1962
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2657 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 18,356,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
210 mg/kg/7D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)- Volume(issue)/page/year: 18,110,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 TOXICOLOGY REVIEW INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3564 No. of Facilities: 549 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 23006 (estimated) No. of Female Employees: 18439 (estimated)

氨苄西林钠安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S22-S36/37-S45-S36-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
XH8400000

[ 海关编码 ]:
2941101900

氨苄西林钠上下游产品

氨苄西林钠上游产品

氨苄西林钠下游产品

氨苄西林钠制备

由氨苄青霉素成盐而得:将氨苄青霉素混悬于水中,用氢氧化钠溶液调节pH至9,溶解,过滤。滤液加活性炭脱色、过滤并将滤液在低温干燥,得产品。

氨苄西林钠海关

[ 海关编码 ]: 2941101900

氨苄西林钠文献

Glucose recognition proteins for glucose sensing at physiological concentrations and temperatures.

ACS Chem. Biol. 9(7) , 1595-602, (2014)

Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods ca...

Phenotypic heterogeneity enables uropathogenic Escherichia coli to evade killing by antibiotics and serum complement.

Infect. Immun. 83(3) , 1056-67, (2015)

Uropathogenic strains of Escherichia coli (UPEC) are the major cause of bacteremic urinary tract infections. Survival in the bloodstream is associated with different mechanisms that help to resist ser...

Anti-tumor effects of flavonoids from the ethnic medicine Docynia delavayi (Franch.) Schneid. and its possible mechanism.

J. Med. Food 17(7) , 787-94, (2014)

This study investigated the active components and the anti-tumor efficacy and mechanisms of the flavonoids from Docynia delavayi (Franch.) Schneid. (DDS). MTT assay was used to examine the growth inhi...


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【氨苄西林钠】化源网提供氨苄西林钠CAS号69-52-3,氨苄西林钠MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氨苄西林钠上化源网,专业又轻松。>>电脑版:氨苄西林钠

标题:氨苄西林钠_MSDS_用途_熔点_氨苄西林钠CAS号【69-52-3】_化源网 地址:https://www.chemsrc.com/amp/cas/69-52-3_895673.html