氨苄西林
氨苄西林用途
氨苄西林作用
药品主要用于敏感菌所致的泌尿系统、呼吸系统、胆道、肠道感染以及脑膜炎、心内膜炎等。
主要用于伤寒、副伤寒的治疗;也用于泌尿道、呼吸道感染。
氨苄西林名称
[ CAS 号 ]:
69-53-4
[ 中文名 ]:
氨苄西林
[ 英文名 ]:
Ampicillin
[中文别名 ]:
[英文别名 ]:
- amfipen
- qidamp
- ay-6108
- binotal
- Wymox
- Unasyn
- MFCD00072036
- p-50
- ab-pc
- EINECS 200-709-7
氨苄西林生物活性
[ 描述 ]:
[ 相关类别 ]:
[体外研究]
[体内研究]
[动物实验]
[参考文献]
[相关活性小分子]
氨苄西林物理化学性质
[ 密度 ]:
1.6±0.1 g/cm3
[ 沸点 ]:
644.5±65.0 °C at 760 mmHg
[ 熔点 ]:
198-200 °C (dec.)(lit.)
[ 分子式 ]:
C16H19N3O4S
[ 分子量 ]:
349.405
[ 闪点 ]:
343.6±34.3 °C
[ 精确质量 ]:
349.109619
[ PSA ]:
138.03000
[ LogP ]:
1.65
[ 外观性状 ]:
结晶固体
[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C
[ 折射率 ]:
1.724
[ 储存条件 ]:
库房通风低温干燥
[ 稳定性 ]:
Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents.
[ 水溶解性 ]:
NH4OH 1 M: 50 mg/mL, clear, colorless
氨苄西林毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH8350000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3- dimethyl-7-oxo-, D-(-)-
- CAS REGISTRY NUMBER :
- 69-53-4
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 31
- MOLECULAR FORMULA :
- C16-H19-N3-O4-S
- MOLECULAR WEIGHT :
- 349.44
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMVYZR& F1 F1 GVQ -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 400 mg/kg/4W-I
- TOXIC EFFECTS :
- Blood - agranulocytosis Blood - other changes Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 160 mg/kg/4D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis Blood - thrombocytopenia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3250 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - excitement Musculoskeletal - changes in teeth and supporting structures
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 7500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 4-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 28 mg/L
- REFERENCE :
- HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 3,173,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,153,1990 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81707 No. of Facilities: 1320 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 2942 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81707 No. of Facilities: 1250 (estimated) No. of Industries: 2 No. of Occupations: 13 No. of Employees: 42346 (estimated) No. of Female Employees: 32858 (estimated)
氨苄西林安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H315-H317-H319-H334-H335
[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful
[ 风险声明 (欧洲) ]:
R36/37/38;R42/43
[ 安全声明 (欧洲) ]:
S22-S26-S36/37
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
2
[ RTECS号 ]:
XH8425000
[ 包装等级 ]:
I; II; III
[ 海关编码 ]:
2941109200
氨苄西林合成路线
氨苄西林上下游产品
氨苄西林上游产品
氨苄西林下游产品
氨苄西林制备
先将D(-)-苯甘氨酸的侧链羧酸用氯化剂PCI5。做成酰氯,再与6-APA进行缩合反应而得。在反应罐中加入丙酮和水,降温到-5--10℃时加入6-APA,再加盐酸苯甘氨酰氯,反应0.5h后用10%氢氧化钠调节pH至3.5。反应物用甲苯萃取。取水层,用10%氨水调节pH值约3.0。用活性炭脱色,并过滤。滤液再用氨水调节使pH为4.8。静置,然后过滤,用丙酮洗涤,在40℃以下进行真空干燥得产品。
氨苄西林海关
[ 海关编码 ]: 2941109200
氨苄西林文献
J. Virol. 89(8) , 4421-33, (2015)
The minimum requirement for an active RNA-dependent RNA polymerase of respiratory syncytial virus (RSV) is a complex made of two viral proteins, the polymerase large protein (L) and the phosphoprotein...
BBS4 directly affects proliferation and differentiation of adipocytes.Cell. Mol. Life Sci. 71(17) , 3381-92, (2014)
BBS4 is one of several proteins whose defects cause Bardet-Biedl syndrome (BBS), a multi-systemic disorder, manifesting with marked obesity. BBS4 polymorphisms have been associated with common non-syn...
An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.Proc. Natl. Acad. Sci. U. S. A. 112(7) , E747-56, (2015)
The nucleotide cyclic di-3',5'- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP-producing bacteria, al...
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价格:
¥318.0/25g
¥138.0/5g
¥848.0/100g
联系人:刘佳
产品详情:氨苄西林
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区域:上海市浦东新区
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¥需询单/1g
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¥489.0/50mg
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氨苄西林相关知识
2018-12-25 17:23:42
导读:氨苄西林(Ampicillin-Xincat),商品名伊西德胶囊。感冒继发感染,支气感炎,肺炎等 胆囊及胆道感染,急性胃肠炎、细菌性痢疾、伤寒及副伤寒 淋病、非淋病性尿路感染等 蜂窝组织炎、皮肤溃疡感染等 败血症、脑膜炎、心内膜炎、腹膜及腹腔内感染、白喉、百日咳等。本药品被归类到胰腺炎等药品...
相关化合物
【氨苄西林】化源网提供氨苄西林CAS号69-53-4,氨苄西林MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氨苄西林上化源网,专业又轻松。>>电脑版:氨苄西林
标题:氨苄西林_作用_用途_密度_氨苄西林CAS号【69-53-4】_化源网 地址:https://www.chemsrc.com/amp/cas/69-53-4_161652.html