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次乌头碱

次乌头碱用途

次乌头碱 (Hypaconitine) 是从乌头属种分离到的高毒性的天然活性成分,广泛用于治疗风湿病。

次乌头碱名称

[ CAS 号 ]:
6900-87-4

[ 中文名 ]:
次乌头碱

[ 英文名 ]:
Hypaconitine

[中文别名 ]:

[英文别名 ]:

Japaconitine C1
HYPACONITINE (PRIMARY STANDARD)
Japaconitine B1
DEOXYMESACONITINE
Japaconitine C

次乌头碱生物活性

[ 描述 ]:

次乌头碱 (Hypaconitine) 是从乌头属种分离到的高毒性的天然活性成分,广泛用于治疗风湿病。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> TNF受体

天然产物 >> 生物碱

研究领域 >> 炎症/免疫

[参考文献]

[1]. Ling Ye, et al. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicology letters, 2011, 204 (1): 81-91

[2]. Yang Yuan, et al. Difference of hypaconitine concentration in serum between cold-deficiency and normal mice. China Journal of Chinese Materia Medica, 2010-15

[3]. Zhang Jinming, Compatibility Effect between Radix Aconiti Lateralis and Radix Glycyrrhizae on Pharmacokinetics of Hypaconitine in Rat Plasma by LC-MS/MS. World Science Technology-Modernization of Traditional Chinese Medicine, 2011-06

[相关活性小分子]

次乌头碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
671.3±55.0 °C at 760 mmHg

[ 分子式 ]:
C₃₃H₄₅NO₁₀

[ 分子量 ]:
615.711

[ 闪点 ]:
359.8±31.5 °C

[ 精确质量 ]:
615.304321

[ PSA ]:
133.22000

[ LogP ]:
0.92

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.607

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

次乌头碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5565000

CHEMICAL NAME :: Aconitane-8,13,14,15-tetraol, 16,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate benzoate, (1-alpha,6-alpha,14-alpha,15-alpha,16-beta)-

CAS REGISTRY NUMBER :: 6900-87-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C33-H45-N-O10

MOLECULAR WEIGHT :: 615.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,170,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 35,159,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

次乌头碱安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P301 + P310 + P330

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
UN 1544

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29399990

次乌头碱

次乌头碱用途

次乌头碱名称

次乌头碱生物活性

次乌头碱物理化学性质

次乌头碱毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

次乌头碱安全信息

次乌头碱合成路线

详细合成路线

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