吡氟氯禾灵

吡氟氯禾灵用途

Haloxyfop 是一种芳氯氧苯氧丙酸除草剂 (herbicide),广泛应用于阔叶作物的野草。Haloxyfop 对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 的抑制作的 IC50 为 0.5 μM,而对豌豆中该酶无影响。

吡氟氯禾灵名称

[ CAS 号 ]:
69806-34-4

[ 中文名 ]:
氟吡禾灵

[ 英文名 ]:
haloxyfop

[中文别名 ]:

[英文别名 ]:

Haloxyfop (free acid)
(RS)-Haloxyfop
2-[4-[3-chloro-5-(tr
HALOXYFOP PESTANAL
Halossifop
T6NJ BOR DOY1&VQ& CG EXFFF
Haloxyfop acid
MFCD00871401
haloxyfop
DOWCO453

吡氟氯禾灵生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

IC50: 0.5 μM (acetyl coenzyme A carboxylase (EC 6.4.1.2))[2]

[参考文献]

[1]. Urairat Koesukwiwat, et al. Method Development and Validation for Total Haloxyfop Analysis in Infant Formulas and Related Ingredient Matrices Using Liquid Chromatography-Tandem Mass Spectrometry. Anal Bioanal Chem

[2]. J D Burton, et al. Inhibition of Plant Acetyl-Coenzyme A Carboxylase by the Herbicides Sethoxydim and Haloxyfop. Biochem Biophys Res Commun

吡氟氯禾灵物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
420.3±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₁ClF₃NO₄

[ 分子量 ]:
361.700

[ 闪点 ]:
208.0±28.7 °C

[ 精确质量 ]:
361.032867

[ PSA ]:
68.65000

[ LogP ]:
2.80

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
0-6°C

吡氟氯禾灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA2458284

CHEMICAL NAME :: Propanoic acid, 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)p henoxy)-

CAS REGISTRY NUMBER :: 69806-34-4

LAST UPDATED :: 199606

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H11-Cl-F3-N-O4

MOLECULAR WEIGHT :: 361.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg/4W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 28,71,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg/4W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 28,71,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1820 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 28,71,1995

吡氟氯禾灵安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
UA2458284

吡氟氯禾灵合成路线

详细合成路线

吡氟氯禾灵上下游产品

吡氟氯禾灵上游产品

吡氟氯禾灵下游产品

吡氟氯禾灵制备

由4-(3-氯-5-三氟甲基吡啶-2-基氧基)苯酚与2-氯代丙酸甲酯在碱性条件下反应生成。

制备方法一

制备方法二

吡氟氯禾灵文献

Enantiomers separation by nano-liquid chromatography: use of a novel sub-2 μm vancomycin silica hydride stationary phase.

J. Chromatogr. A. 1381 , 149-59, (2015)

A novel sub-2 μm chiral stationary phase (CSP) was prepared immobilizing vancomycin onto 1.8 μm diol hydride-based silica particles. The CSP was packed into fused silica capillaries of 75 μm i.d. with...

Environmental behavior of the chiral herbicide haloxyfop. 1. Rapid and preferential interconversion of the enantiomers in soil.

J. Agric. Food Chem. 63(10) , 2583-90, (2015)

Haloxyfop-methyl is a chiral herbicide that was first introduced as racemate and later replaced by "haloxyfop-P-methyl", mainly consisting of the R-enantiomer, which carries the herbicidal activity. W...

Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum.

Antimicrob. Agents Chemother. 51 , 307-16, (2007)

Targeting of apicoplast replication and protein synthesis in the apicomplexan Toxoplasma gondii has conventionally been associated with the typical "delayed death" phenotype, characterized by the deat...

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