盐酸麦塞散

盐酸麦塞散用途

Metixene hydrochloride hydrate 是一种抗胆碱能、抗帕金森剂,能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体 (muscarinic receptor) 结合,IC50 和 Kd 值分别为 55 nM 和 15 nM。

盐酸麦塞散名称

[ CAS 号 ]:
7081-40-5

[ 中文名 ]:
盐酸麦塞散

[ 英文名 ]:
Metixene hydrochloride hydrate

[中文别名 ]:

盐酸美噻吨

[英文别名 ]:

Methixene hydrochloride hydrete
Methixene hydrochloride hydrate

盐酸麦塞散生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[ 靶点 ]

IC50: 55 nM (mAChR)[1] Ki: 15 nM (mAChR)[1]

[体外研究]

盐酸Metixene水合物是一种抗胆碱能抗帕金森病药物,有效抑制大鼠脑皮质组织中奎宁环丙烯酸酯(QNB)与毒蕈碱受体的结合,IC50为55 nM,Kd为15 nM [1]。

[参考文献]

[1]. Syvälahti EK, et al. Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacol Toxicol. 1988 Feb;62(2):90-4.

盐酸麦塞散物理化学性质

[ 沸点 ]:
419.7ºC at 760 mmHg

[ 熔点 ]:
215-217°

[ 分子式 ]:
C₂₀H₂₆ClNOS

[ 分子量 ]:
363.94500

[ 精确质量 ]:
363.14200

[ PSA ]:
37.77000

[ LogP ]:
5.69060

盐酸麦塞散安全信息

[ 海关编码 ]:
2934999090

盐酸麦塞散海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸麦塞散文献

[An anticholinergic agent, the side effect of mouth dryness and hazards for the teeth].

Ned. Tijdschr. Geneeskd. 127(51) , 2318-21, (1983)

Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism.

J. Neural Transm. Suppl. 25 , 137-47, (1987)

To quantify the clinical benefit of an additional deprenyl administration in L-dopa pretreated patients we have performed a study of 30 patients suffering from advanced parkinsonism. During the first ...

Evaluation of an antispasmodic agent. Methixene hydrochloride (Trest).

JAMA 195(10) , 851, (1966)

Methixene hydrochloride, an anticholinergic agent, may be useful in the symptomatic treatment of functional bowel disorders. Adverse effects reported from its use are those of the anticholinergic drug...

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