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5-甲氧基吲哚-3-乙醇

5-甲氧基吲哚-3-乙醇用途

5-Methoxytryptophol是松果体中存在的天然吲哚。

5-甲氧基吲哚-3-乙醇名称

[ CAS 号 ]:
712-09-4

[ 中文名 ]:
5-甲氧基吲哚-3-乙醇

[ 英文名 ]:
5-methoxytryptophol

[中文别名 ]:

5-甲氧基色醇

[英文别名 ]:

EINECS 211-919-3
MFCD00047196
2-(5-methoxy-1H-indol-3-yl)ethanol

5-甲氧基吲哚-3-乙醇生物活性

[ 描述 ]:

5-Methoxytryptophol是松果体中存在的天然吲哚。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Satué M, et al. A new role for 5-methoxytryptophol on bone cells function in vitro. J Cell Biochem. 2015 Apr;116(4):551-8.

[2]. Raynaud F, et al. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin after 5-methoxytryptamine administration of golden hamsters: physiological implications. J Neural Transm Gen Sect. 1991;84(1-2):33-43.

[相关活性小分子]

5-甲氧基吲哚-3-乙醇物理化学性质

[ 密度 ]:
1.224 g/cm3

[ 沸点 ]:
393.9ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₃NO₂

[ 分子量 ]:
191.22600

[ 闪点 ]:
192ºC

[ 精确质量 ]:
191.09500

[ PSA ]:
45.25000

[ LogP ]:
1.71130

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
1.64

[ 储存条件 ]:
2-8°C

5-甲氧基吲哚-3-乙醇MSDS

5-甲氧基吲哚-3-乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL8513000

CHEMICAL NAME :: Indole-3-ethanol, 5-methoxy-

CAS REGISTRY NUMBER :: 712-09-4

BEILSTEIN REFERENCE NO. :: 0145680

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H13-N-O2

MOLECULAR WEIGHT :: 191.25

WISWESSER LINE NOTATION :: T56 BMJ D2Q GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 9333 ug/kg

SEX/DURATION :: female 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 145,63,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 25200 ug/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 30,305,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 240 mg/kg

SEX/DURATION :: female 1-2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JNTMAH Journal of Neural Transmission. (Springer-Verlag, Postfach 367, A-1011 Vienna, Austria) V.33-77, 1972-89. Volume(issue)/page/year: 96,19,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 750 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 83,599,1968

5-甲氧基吲哚-3-乙醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL8513000

[ 海关编码 ]:
2933990090

5-甲氧基吲哚-3-乙醇合成路线

5-甲氧基吲哚-3-乙醇上下游产品

5-甲氧基吲哚-3-乙醇上游产品

5-甲氧基吲哚-3-乙醇下游产品

5-甲氧基吲哚-3-乙醇海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-甲氧基吲哚-3-乙醇文献

Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.

Biochem. Biophys. Res. Commun. 282(5) , 1229-36, (2001)

Site-directed mutation of serine 110 (Ser(3.35)) and serine 114 (Ser(3.39)) in the human melatonin MT(1) receptor to alanine residues reduced ligand binding affinities of seven known melatonin recepto...

Effects of cycloheximide and aminophylline on 5-methoxytryptophol and melatonin contents in the chick pineal gland.

Gen. Comp. Endocrinol. 120(2) , 212-9, (2000)

The chick pineal gland rhythmically synthesizes two 5-methoxyindoles, melatonin and 5-methoxytryptophol. These rhythms are circadian in nature and have opposite phases. The aim of this study was to de...

5-methoxytryptophol preserves hepatic microsomal membrane fluidity during oxidative stress.

J. Cell. Biochem. 76(4) , 651-7, (2000)

Lipid peroxidation is a degenerative chain reaction in biological membranes that may be initiated by exposure to free radicals. This process is associated with changes in the membrane fluidity and los...

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