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BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE

用途

苏氨酸丝氨酸赖氨酸是一种牛松果体抗生殖三肽,具有抗促性腺激素活性。苏氨酸丝氨酸赖氨酸在由LHRH 2-5[1][3]组成的位点与黄体生成素释放激素(LHRH)结合。

名称

[ CAS 号 ]:
71730-64-8

[ 中文名 ]:
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE

[ 英文名 ]:
Bovine Pineal Antireproductive Tripeptide acetate salt

[英文别名 ]:

H-Thr-Ser-Lys-OH
THR-SER-LYS
threonyl-seryl-lysine
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE
thr-ser-lys acetate
threonine-serine-lysine acetate
H-THR-SER-LYS-OH ACETATE SALT
L-Lysine,N2-(N-L-threonyl-L-seryl)
THR-SER-LYS (THR-SER-LYS ACETATE)

生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

[体内研究]

苏氨酸丝氨酸赖氨酸(175 ng,i.p.)可减少单侧去卵巢(UO)小鼠5天的代偿性卵巢肥大[1]。苏氨酸丝氨酸赖氨酸(1或5μg,i.p.)延迟雌性Charles River CD大鼠的阴道开放时间[2]。苏氨酸丝氨酸赖氨酸(1和10μg,皮下注射15天)会增加小鼠卵巢和肾上腺的重量[4]。动物模型：单侧去卵巢(UO)小鼠剂量：175 ng给药：腹腔注射(i.p.)结果：UO小鼠血清卵泡刺激素(FSH)降低。

[参考文献]

[1]. Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5.

[2]. Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7.

[3]. Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28.

[4]. Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172.