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顺式ACBD(1-氨基环丁烷-1

顺式ACBD(1-氨基环丁烷-1用途

顺式ACBD是高亲和力、依赖钠离子的质膜谷氨酸转运体的有效和选择性抑制剂。顺式ACBD是一种谷氨酸再摄取抑制剂。顺式ACBD也可作为D-[3H]天冬氨酸摄取的线性竞争抑制剂[1][2]。

顺式ACBD(1-氨基环丁烷-1名称

[ CAS 号 ]:
73550-55-7

[ 中文名 ]:
1-氨基环丁烷-反式-1,3-二羧酸

[ 英文名 ]:
cis-ABCD

[中文别名 ]:

1-氨基环丁烷-1,3-顺式二羧酸

[英文别名 ]:

CIS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
5-Methylfurmethiodide
TRANS-1-AMINOCYCLOBUTANE-1,3-DICARBOXYLIC ACID
CIS-2,4-METHANOGLUTAMIC ACID
CIS-ACBD
cis-1-Aminocyclobutan-1,3-dicarboxylic acid
1-amino-1,3-dicarboxycyclobutane
trans-2,4-methanoglutamic acid
1-AMINOCYCLOBUTANE-TRANS-1,3-DICARBOXYLIC ACID
2-methanoglutamic acid

顺式ACBD(1-氨基环丁烷-1生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Ai J, et al. Presynaptic excitability as a potential target for the treatment of the traumatic cerebellum. Pharmacology. 2004 Aug;71(4):192-8.

[2]. Griffiths R, et al. L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters. Biochem Pharmacol. 1994 Jan 20;47(2):267-74.

顺式ACBD(1-氨基环丁烷-1物理化学性质

[ 密度 ]:
1.568g/cm3

[ 沸点 ]:
288.1ºC at 760 mmHg

[ 分子式 ]:
C₆H₉NO₄

[ 分子量 ]:
159.14000

[ 闪点 ]:
128ºC

[ 精确质量 ]:
159.05300

[ PSA ]:
100.62000

[ 折射率 ]:
1.587

顺式ACBD(1-氨基环丁烷-1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU1685000

CHEMICAL NAME :: 1,3-Cyclobutanedicarboxylic acid, 1-amino-, cis-, hydrate

CAS REGISTRY NUMBER :: 73550-55-7

LAST UPDATED :: 199109

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H9-N-O4.H2-O

MOLECULAR WEIGHT :: 177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,2905,1990