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Α-甲基-DL-酪氨酸甲酯盐酸盐

Α-甲基-DL-酪氨酸甲酯盐酸盐用途

α-甲基酪氨酸甲酯盐酸盐是一种竞争性酪氨酸羟化酶抑制剂,抑制酪氨酸向多巴胺的转化。α-甲基酪氨酸甲酯盐酸盐可用作交感神经系统研究的工具[1]。

Α-甲基-DL-酪氨酸甲酯盐酸盐名称

[ CAS 号 ]:
7361-31-1

[ 中文名 ]:
Alpha-甲基-DL-酪氨酸甲酯盐酸盐

[ 英文名 ]:
alpha-methyl-dl-tyrosine methyl ester hydrochloride

[中文别名 ]:

Α-甲基-DL-酪氨酸甲酯盐酸盐

[英文别名 ]:

MFCD00012606
EINECS 230-900-0
AMPT

Α-甲基-DL-酪氨酸甲酯盐酸盐生物活性

[ 描述 ]:

α-甲基酪氨酸甲酯盐酸盐是一种竞争性酪氨酸羟化酶抑制剂,抑制酪氨酸向多巴胺的转化。α-甲基酪氨酸甲酯盐酸盐可用作交感神经系统研究的工具[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. G Magnusson, et al. Renal lesions induced by alpha-methyltyrosine methylester and alpha-methyltyrosine. Acta Pharmacol Toxicol (Copenh). 1970;28(6):435-44.

Α-甲基-DL-酪氨酸甲酯盐酸盐物理化学性质

[ 沸点 ]:
336.4ºC at 760 mmHg

[ 熔点 ]:
192 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₁₆ClNO₃

[ 分子量 ]:
245.70300

[ 闪点 ]:
157.2ºC

[ 精确质量 ]:
245.08200

[ PSA ]:
72.55000

[ LogP ]:
2.32740

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 50 mg/mL, clear, faintly yellow

Α-甲基-DL-酪氨酸甲酯盐酸盐MSDS

详细MSDS(安全技术说明书)

Α-甲基-DL-酪氨酸甲酯盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2900000

CHEMICAL NAME :: p-Tyrosine, alpha-methyl-, methyl ester, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 7361-31-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N-O3.Cl-H

MOLECULAR WEIGHT :: 245.73

WISWESSER LINE NOTATION :: QR D1XZ1&VO1 &GH, -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

Α-甲基-DL-酪氨酸甲酯盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YP2900000

[ 海关编码 ]:
2922509090

Α-甲基-DL-酪氨酸甲酯盐酸盐海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Α-甲基-DL-酪氨酸甲酯盐酸盐文献

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Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.

Br. J. Pharmacol. 141(1) , 132-40, (2004)

1. The ORL1 agonists nociceptin and Ro 64-6198 were compared in their ability to modify spontaneous locomotor activity in male NMRI mice not habituated to the test environment. 2. Higher doses of noci...

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