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4-羟乙基哌嗪乙磺酸

4-羟乙基哌嗪乙磺酸用途

HEPES 是一种两性离子化学缓冲剂,广泛应用于细胞培养。HEPES 在 pH 值为 6.8 至 8.2 时为有效的缓冲液。HEPES 是溶酶体生物发生的有效诱导剂。

4-羟乙基哌嗪乙磺酸名称

[ CAS 号 ]:
7365-45-9

[ 中文名 ]:
4-羟乙基哌嗪乙磺酸

[ 英文名 ]:
HEPES

[中文别名 ]:

[英文别名 ]:

4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
hepesfreeacid
4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid
HEPES.1/2Na
EIT hydrobromide
hepes solution
GOOD'S BUFFER
HEPES
HEPES BUFFER PH 8.0
EINECS 230-907-9

4-羟乙基哌嗪乙磺酸生物活性

[ 描述 ]:

HEPES 是一种两性离子化学缓冲剂,广泛应用于细胞培养。HEPES 在 pH 值为 6.8 至 8.2 时为有效的缓冲液。HEPES 是溶酶体生物发生的有效诱导剂。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.

[2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492.

[3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

4-羟乙基哌嗪乙磺酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
234-238 °C

[ 分子式 ]:
C₈H₁₈N₂O₄S

[ 分子量 ]:
238.305

[ 精确质量 ]:
238.098724

[ PSA ]:
89.46000

[ LogP ]:
-2.67

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
1.543

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture.

[ 水溶解性 ]:
Soluble

4-羟乙基哌嗪乙磺酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6809000

CHEMICAL NAME :: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 7365-45-9

BEILSTEIN REFERENCE NO. :: 0883043

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H18-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9468 No. of Facilities: 239 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3025 (estimated) No. of Female Employees: 2233 (estimated)

4-羟乙基哌嗪乙磺酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25-S22-S36-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TL6809000

[ 海关编码 ]:
29335995

4-羟乙基哌嗪乙磺酸海关

[ 海关编码 ]: 29335995

4-羟乙基哌嗪乙磺酸文献

Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

PLoS Biol. 12(1) , e1001758, (2014)

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of ep...

Functional consequence of the MET-T1010I polymorphism in breast cancer.

Oncotarget 6(5) , 2604-14, (2015)

Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor rec...

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.

PLoS ONE 9(12) , e116152, (2014)

Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses ...

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