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4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)用途

HEPPS(EPPS)是一种缓冲剂,有效pH值范围为7.3~8.7。HEPPS可减少aβ-聚集物诱导的小鼠记忆障碍,并挽救认知障碍。EPPS具有口服活性,可穿透血脑屏障[1]。

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)名称

[ CAS 号 ]:
16052-06-5

[ 中文名 ]:
4-羟乙基哌嗪丙磺酸

[ 英文名 ]:
HEPPS

[中文别名 ]:

[英文别名 ]:

HEPPS
EINECS 240-198-8
MFCD00006160
EPPS
4-Hydroxyerhylpiperazine-1-propanesulfonic acid

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)生物活性

[ 描述 ]:

HEPPS(EPPS)是一种缓冲剂,有效pH值范围为7.3~8.7。HEPPS可减少aβ-聚集物诱导的小鼠记忆障碍,并挽救认知障碍。EPPS具有口服活性,可穿透血脑屏障[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
237-239 °C(lit.)

[ 分子式 ]:
C₉H₂₀N₂O₄S

[ 分子量 ]:
252.331

[ 精确质量 ]:
252.114380

[ PSA ]:
89.46000

[ LogP ]:
-2.46

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
1.537

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
H2O: 1 M at 20 °C, clear, colorless

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)MSDS

详细MSDS(安全技术说明书)

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2649130

CHEMICAL NAME :: 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 16052-06-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H20-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TM2649130

[ 海关编码 ]:
29335995

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(2-羟乙基)-1-哌嗪丙磺酸(HEPPS)文献

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.

J. Pharmacol. Toxicol. Methods 70(2) , 188-94, (2014)

Malaria is a major health concern and affects over 300million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-mala...

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

J. Biol. Chem. 290 , 21615-28, (2015)

Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide...

EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques.

Nat. Commun. 6 , 8997, (2015)

Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical sympto...

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