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Imiclopazine

Imiclopazine用途

Imiclopazine 是一种吩噻嗪衍生物,具有良好的镇静,镇痛,抗攻击和止吐作用。

Imiclopazine名称

[ CAS 号 ]:
7414-95-1

[ 中文名 ]:
盐酸环丙哌嗪

[ 英文名 ]:
Imiclopazine

[英文别名 ]:

Chlorimpiphenine dihydrochloride
Chorimpiphenine
P-4241
Chlorimiphene dichloride
Ponsital
Imiclopazine hydrochloride
Chlorimphenine hydrochloride
Imiclopazine dihydrochloride
Asta p 4241

Imiclopazine生物活性

[ 描述 ]:

Imiclopazine 是一种吩噻嗪衍生物,具有良好的镇静,镇痛,抗攻击和止吐作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

咪氯哌嗪在P388和P388/ADR细胞中表现出多药耐药(MDR)逆转活性,EC50值均为200μM[2]。

[参考文献]

[1]. A Ramu, et al. Reversal of multidrug resistance by phenothiazines and structurally related compounds. Cancer Chemother Pharmacol. 1992;30(3):165-73.

[2]. D. Lenke, et al. Pharmacological activity of new phenothiazine and azaphenothiazine derivatives. January 1971, Arzneimittel-Forschung. 21:288-293.

Imiclopazine物理化学性质

[ 密度 ]:
1.252g/cm3

[ 沸点 ]:
659.8ºC at 760mmHg

[ 分子式 ]:
C₂₅H₃₂ClN₅OS

[ 分子量 ]:
486.07200

[ 闪点 ]:
352.8ºC

[ 精确质量 ]:
485.20200

[ PSA ]:
58.57000

[ LogP ]:
4.13440

Imiclopazine毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ0621400

CHEMICAL NAME :: 2-Imidazolidinone, 1-(2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-pipe razinyl)ethyl)-3- methyl-, dihydrochloride

CAS REGISTRY NUMBER :: 7414-95-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C25-H32-Cl-N5-O-S.2Cl-H

MOLECULAR WEIGHT :: 559.05

WISWESSER LINE NOTATION :: T C666 BN ISJ EG B3- AT6N DNTJ D2- AT5NVNTJ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 321 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,317,1967