<生产厂家价格>

3-马来酰亚胺基丙酸

3-马来酰亚胺基丙酸用途

3-Maleimidopropionic acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

3-马来酰亚胺基丙酸名称

[ CAS 号 ]:
7423-55-4

[ 中文名 ]:
3-马来酰亚胺基丙酸

[ 英文名 ]:
3-Maleimidopropionic acid

[中文别名 ]:

[英文别名 ]:

BMPA
β-Maleimidopropionic acid
MFCD00043030
3-(2,5-dioxopyrrol-1-yl)propanoic acid
3-Maleimidopropionic acid
3-Maleimidopropionicacid

3-马来酰亚胺基丙酸生物活性

[ 描述 ]:

3-Maleimidopropionic acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

3-马来酰亚胺基丙酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
382.5±25.0 °C at 760 mmHg

[ 熔点 ]:
103-106 °C(lit.)

[ 分子式 ]:
C₇H₇NO₄

[ 分子量 ]:
169.135

[ 闪点 ]:
185.1±23.2 °C

[ 精确质量 ]:
169.037506

[ PSA ]:
74.68000

[ LogP ]:
0.04

[ 外观性状 ]:
白色至淡黄色固体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.565

[ 储存条件 ]:
-15°C

[ 水溶解性 ]:
可溶于：甲醇

3-马来酰亚胺基丙酸MSDS

3-马来酰亚胺基丙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925190090

3-马来酰亚胺基丙酸合成路线

3-马来酰亚胺基丙酸上下游产品

3-马来酰亚胺基丙酸上游产品

3-马来酰亚胺基丙酸下游产品

3-马来酰亚胺基丙酸海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

3-马来酰亚胺基丙酸文献

Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with (89)Zr(4+): comparison with desferrioxamine-B.

Dalton Trans. 44(11) , 4884-900, (2015)

Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging...

Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.

J. Biol. Chem. 290 , 17956-66, (2015)

Acid-sensing ion channels (ASICs) are neuronal, voltage-independent Na(+) channels that are transiently activated by extracellular acidification. They are involved in pain sensation, the expression of...

Selective and Sensitive Sensing of Flame Retardant Chemicals Through Phage Display Discovered Recognition Peptide.

Nano Lett. 15 , 7697-703, (2015)

We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominate...

更多文献