1,1,1,2-四氯-2,2-二氟乙烷

1,1,1,2-四氯-2,2-二氟乙烷用途

药物麻醉剂甲氧氟烷的中间体；可作发泡剂、抛射剂、制冷剂。

1,1,1,2-四氯-2,2-二氟乙烷名称

[ CAS 号 ]:
76-11-9

[ 中文名 ]:
1,1,1,2-四氯-2,2-二氟乙烷

[ 英文名 ]:
1,1,1,2-tetrachloro-2,2-difluoroethane

[中文别名 ]:

[英文别名 ]:

1-chloro-1,1-difluoro-2,2,2-trichloro-ethane
f112a
tetrachlorodifluoroethane
1,1-difluoro-1,2,2,2-tetrachloroethane
MFCD00000798
Fron-112a
freon112a
tetrachloro-2,2-difluoroethane
2,2-DIFLUORO-5-AMINO-6-CHLORO-1,3-BENZODIOXOLE
cfc112a

1,1,1,2-四氯-2,2-二氟乙烷物理化学性质

[ 密度 ]:
1.726 g/cm3

[ 沸点 ]:
93.3ºC at 760 mmHg

[ 熔点 ]:
39-44ºC

[ 分子式 ]:
C₂Cl₄F₂

[ 分子量 ]:
203.83000

[ 闪点 ]:
11.8ºC

[ 精确质量 ]:
201.87200

[ LogP ]:
3.18820

[ 外观性状 ]:
无色结晶固体

[ 折射率 ]:
1.4046

[ 储存条件 ]:
库房低温,通风,干燥,密闭保存

1,1,1,2-四氯-2,2-二氟乙烷MSDS

详细MSDS(安全技术说明书)

1,1,1,2-四氯-2,2-二氟乙烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI1425000

CHEMICAL NAME :: Ethane, 2,2-difluoro-1,1,1,2-tetrachloro-

CAS REGISTRY NUMBER :: 76-11-9

BEILSTEIN REFERENCE NO. :: 1699461

LAST UPDATED :: 199712

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C2-Cl4-F2

MOLECULAR WEIGHT :: 203.82

WISWESSER LINE NOTATION :: GXGGXGFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 210,744,1966

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20000 ppm/30M

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,1,1971 *** REVIEWS *** ACGIH TLV-TWA 4170 mg/m3 (500 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 500 ppm (4170 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,249,1971 OSHA PEL (Gen Indu):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 500 ppm (4170 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-BELGIUM:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-DENMARK:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-FINLAND:TWA 500 ppm (4170 mg/m3);STEL 625 ppm (5215 mg/m3) JAN 1993 OEL-FRANCE:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-GERMANY:TWA 1000 ppm (8340 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 500 ppm (4170 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 500 ppm (4200 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (834 mg/m3);STEL 100 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1,1,2-TETRACHLORO-2,2-DIFLUOROETHANE-air:TWA 500 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

1,1,1,2-四氯-2,2-二氟乙烷安全信息

[ 危害码 (欧洲) ]:
N: Dangerous for the environment;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R59;R36/37/38

[ 安全声明 (欧洲) ]:
S59-S37/39-S26

1,1,1,2-四氯-2,2-二氟乙烷合成路线

详细合成路线

1,1,1,2-四氯-2,2-二氟乙烷上下游产品

1,1,1,2-四氯-2,2-二氟乙烷上游产品

1,1,1,2-四氯-2,2-二氟乙烷下游产品

1,1,1,2-四氯-2,2-二氟乙烷制备

搅拌下将无水三氯化铝迅速加入己熔化的氟里昂112中，保温搅拌2-3h，再升温至60-70℃，保温过滤，滤液分馏，收集91-92℃馏分，得2,2-二氟四氯乙烷。收率70%。