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3-巯基-2苄基丙基甘氨酸

3-巯基-2苄基丙基甘氨酸用途

噻吩是一种选择性NEP(尼泊尔溶素)抑制剂,IC50为6.9 nM【1】。

3-巯基-2苄基丙基甘氨酸名称

[ CAS 号 ]:
76721-89-6

[ 中文名 ]:
3-巯基-2苄基丙基甘氨酸

[ 英文名 ]:
Thiorphan

[中文别名 ]:

[英文别名 ]:

N-[(RS)-2-Benzyl-3-mercaptopropanoyl]-glycine
DL-[N-(3-mercapto-2-benzylpropanoyl)]glycine
N-[(R,S)-3-mercapto-2-benzyl-propionyl]glycine
DL-Thiorphan
Tiorphan
N-(2-Benzyl-3-sulfanylpropanoyl)glycine
DL-3-Mercapto-2-benzylpropanoylglycine
Prestwick_694
N-(3-mercapto-2-benzylpropanoyl)glycine
(2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE

3-巯基-2苄基丙基甘氨酸生物活性

[ 描述 ]:

噻吩是一种选择性NEP(尼泊尔溶素)抑制剂,IC50为6.9 nM【1】。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 代谢酶/蛋白酶 >> 脑啡肽酶

[参考文献]

[1]. Whyteside AR, Turner AJ. Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 2008 Jul 9;582(16):2382-6.

3-巯基-2苄基丙基甘氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
524.0±50.0 °C at 760 mmHg

[ 熔点 ]:
138-140ºC

[ 分子式 ]:
C₁₂H₁₅NO₃S

[ 分子量 ]:
253.32

[ 闪点 ]:
270.7±30.1 °C

[ 精确质量 ]:
253.077271

[ PSA ]:
105.20000

[ LogP ]:
1.37

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.577

[ 储存条件 ]:
室温

3-巯基-2苄基丙基甘氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2930909090

3-巯基-2苄基丙基甘氨酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-巯基-2苄基丙基甘氨酸文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

J. Pharmacol. Exp. Ther. 346(1) , 31-7, (2013)

The serine protease chymase has been reported to generate intracardiac angiotensin-II (Ang-II) from Ang-I as well as an intermediate precursor of endothelin-1 (ET-1), ET-1 (1-31) from Big-ET-1. Althou...

A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.

J. Assoc. Physicians India 60 , 12-5, (2012)

To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea.A randomized control study was done in th...

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