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三(羟甲基)氨基甲烷

三(羟甲基)氨基甲烷用途

Trometamol 是一种低毒性的生物惰性氨基醇,可以在体内和体外缓冲二氧化碳和酸。Trometamol 是一种在生理范围内控制 pH 值的有效胺类化合物。

三(羟甲基)氨基甲烷名称

[ CAS 号 ]:
77-86-1

[ 中文名 ]:
三羟甲基氨基甲烷

[ 英文名 ]:
Trometamol

[中文别名 ]:

[英文别名 ]:

EINECS 201-064-4
Tham-E
THAM
Talatrol
Trizma
TRIS
8VTE 1L
thamset
MFCD00004679
riladyl

三(羟甲基)氨基甲烷生物活性

[ 描述 ]:

Trometamol 是一种低毒性的生物惰性氨基醇,可以在体内和体外缓冲二氧化碳和酸。Trometamol 是一种在生理范围内控制 pH 值的有效胺类化合物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998 Feb;55(2):191-224.

三(羟甲基)氨基甲烷物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
357.0±37.0 °C at 760 mmHg

[ 熔点 ]:
167-172 °C(lit.)

[ 分子式 ]:
C₄H₁₁NO₃

[ 分子量 ]:
121.135

[ 闪点 ]:
169.7±26.5 °C

[ 精确质量 ]:
121.073891

[ PSA ]:
86.71000

[ LogP ]:
-1.38

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.544

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.

[ 水溶解性 ]:
550 g/L (25 ºC)

三(羟甲基)氨基甲烷MSDS

三(羟甲基)氨基甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY2900000

CHEMICAL NAME :: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 77-86-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H11-N-O3

MOLECULAR WEIGHT :: 121.16

WISWESSER LINE NOTATION :: Q1XZ1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 110,653,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,419,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 17,217,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - coma

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 22,315,1940 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81165 No. of Facilities: 850 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 7274 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81165 No. of Facilities: 2296 (estimated) No. of Industries: 9 No. of Occupations: 22 No. of Employees: 40897 (estimated) No. of Female Employees: 30773 (estimated)

三(羟甲基)氨基甲烷安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
TY2900000

[ 海关编码 ]:
29221980

三(羟甲基)氨基甲烷合成路线

三(羟甲基)氨基甲烷上下游产品

三(羟甲基)氨基甲烷上游产品

三(羟甲基)氨基甲烷下游产品

三(羟甲基)氨基甲烷制备

1.用相应的硝基化合物还原或催化氢化方法制取。

2.可用硝基甲烷与3mol甲醛作用生成三羟甲基硝基甲烷，再还原成三羟甲基氨基甲烷。

三(羟甲基)氨基甲烷海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

三(羟甲基)氨基甲烷文献

Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.

Biochim. Biophys. Acta 1842(12 Pt A) , 2345-56, (2014)

The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis o...

HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC.

J. Cell. Mol. Med. 18(9) , 1752-61, (2014)

β-catenin nuclear accumulation is frequently identified in human non-small cell lung cancer (NSCLC). The HMG-box transcription factor 1 (HBP1) is a known repressor of β-catenin transactivation. Howeve...

Use of an enzyme-assisted method to improve protein extraction from olive leaves.

Food Chem. 169 , 28-33, (2014)

The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extra...

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