硫酸锌

硫酸锌用途

用作印染媒染剂、木材防腐剂、造纸漂白剂，还用于医药、人造纤维、电解、电镀、农药及生产锌盐等

硫酸锌作用

锌是许多酶系统(如碳酸酐酶、乙醇脱氢酶和碱性磷酸酶等)的组成部分，锌缺乏可导致酶功能异常。口服硫酸锌可纠正锌缺乏，恢复酶系统的功能。锌离子能沉淀蛋白质，外用有收敛防腐作用，且能帮助肉芽组织形成。适用于治疗由于锌缺乏引起的肠病性肢端皮炎、口疮、慢性溃疡、结膜炎等。但与青霉胺共用可使后者作用减弱。
血浆、肝脏、腺胰和骨骼组织是锌的快速交换、储存场所，对日常锌水平的变化很敏感。锌影响动物生长、发育和繁殖功能，影响骨骼和血液的形成及核酸、蛋白质和碳水化合物代谢。与毛的生长、皮肤的健康、创伤的愈合有关。在这些组织上，锌主要与酶结合，作为酶必不可少的组成成分和激活剂。锌是碳酸酐酶胰腺的羧基肽酶、谷氨酸和乳酸脱氢酶等的分子组成成分。可激活尿酸酶、肠液中的二肽酶和其他酶。可通过对垂体、促性腺激素的作用间接对繁殖机能发生作用，一水硫酸锌在饲料中可作为锌元素增补剂。

硫酸锌名称

[ CAS 号 ]:
7733-02-0

[ 中文名 ]:
硫酸锌

[ 英文名 ]:
Zinc sulphate

[英文别名 ]:

Zinc sulphate
Complexonat
zinc(ii) sulfate
Bonazen
Optised
Zinc sulfate solution
Zinc (II) sulfate
zinc,sulfate
EINECS 231-793-3
MFCD00011302

硫酸锌物理化学性质

[ 密度 ]:
1.957

[ 沸点 ]:
330ºC at 760 mmHg

[ 熔点 ]:
100ºC

[ 分子式 ]:
O₄SZn

[ 分子量 ]:
161.472

[ 精确质量 ]:
159.880875

[ PSA ]:
82.98000

[ LogP ]:
0.42550

[ 外观性状 ]:
无色固体

[ 储存条件 ]:
室温，密封，干燥

[ 水溶解性 ]:
H2O: soluble | Soluble

硫酸锌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZH5260000

CAS REGISTRY NUMBER :: 7733-02-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 40

MOLECULAR FORMULA :: O4-S.Zn

MOLECULAR WEIGHT :: 161.43

WISWESSER LINE NOTATION :: ZN S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 45 mg/kg/7D-C

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Gastrointestinal - other changes Blood - normocytic anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 180 mg/kg/6W-I

TOXIC EFFECTS :: Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3120 mg/kg/43W-I

TOXIC EFFECTS :: Blood - microcytosis with or without anemia Blood - agranulocytosis Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 196 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 69900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29060 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 74 mg/kg/3D-I

TOXIC EFFECTS :: Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in calcium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg/60D-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - changes in metals, not otherwise specified

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 7110 mg/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3625 ug/kg/5D-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 333 mg/kg

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 34573 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 15 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 2 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 193 gm/kg

SEX/DURATION :: female 6-20 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 200 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,193,1979 *** REVIEWS *** TOXICOLOGY REVIEW FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 77220 No. of Facilities: 3067 (estimated) No. of Industries: 52 No. of Occupations: 47 No. of Employees: 40653 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 77220 No. of Facilities: 4755 (estimated) No. of Industries: 52 No. of Occupations: 66 No. of Employees: 89451 (estimated) No. of Female Employees: 27887 (estimated)

硫酸锌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H412

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R41;R50/53

[ 安全声明 (欧洲) ]:
S26-S39-S61

[ 危险品运输编码 ]:
UN 3082/9161

[ WGK德国 ]:
3

[ RTECS号 ]:
ZH5260000

[ 海关编码 ]:
2833293000

硫酸锌合成路线

详细合成路线

硫酸锌上下游产品

硫酸锌上游产品

硫酸锌下游产品

硫酸锌制备

1.将一水硫酸锌ZnSO4·H2O加热至280℃左右使其完全脱水即可生成无水硫酸锌。也可用七水硫酸锌ZnSO4·7H2O为起始物，先在较低的温度下缓慢加热，使其逐步脱水变为一水合物，然后将温度升高至280℃左右。

2.闪锌矿经焙烧后浸提、精炼而得。

3.由硫酸与锌或氧化锌反应而得。

4.主要采用酸解法，以氧化锌或其他含锌化合物为原料，用硫酸分解，再经压滤、浓缩、结晶、分离、烘干而得。

硫酸锌海关

[ 海关编码 ]: 2833293000

硫酸锌文献

Formulation, in vitro drug release study and anticancer activity of 5-fluorouracil loaded gellan gum microbeads.

Acta Pol. Pharm. 70(1) , 123-7, (2013)

5-Fluorouracil loaded calcium-zinc-gellan and calcium-zinc-gellan-ethyl cellulose microbeads were successfully prepared by simple ionotropic gelation and oil in water ionotropic gelation technique, re...

Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process.

Int. J. Nanomedicine 6 , 2997-3009, (2011)

The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical a...

[Effect of growth factors and some microelements on biosurfactant synthesis of Acinetobacter calcoaceticus IMV B-7241].

Mikrobiol. Z. 75(5) , 18-26, (2013)

The effect of yeast autolysate and microelements on synthesis of surface-active substances (SAS, biosurfactants) was investigated under cultivation of Acinetobacter calcoaceticus IMV B-7241 on various...

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硫酸锌