7733-02-0

• 常用中文名：硫酸锌
• 常用英文名：Zinc sulphate
• CAS号：7733-02-0
• 分子式：O₄SZn
• 分子量：161.472
• 相关类别： 原料药 维生素类与矿物质类药 微量元素与矿物质类药
• 发布时间：2018-02-07 08:00:00
• 更新时间：2024-01-02 18:03:44
• 用作印染媒染剂、木材防腐剂、造纸漂白剂，还用于医药、人造纤维、电解、电镀、农药及生产锌盐等
• 锌是许多酶系统(如碳酸酐酶、乙醇脱氢酶和碱性磷酸酶等)的组成部分，锌缺乏可导致酶功能异常。口服硫酸锌可纠正锌缺乏，恢复酶系统的功能。锌离子能沉淀蛋白质，外用有收敛防腐作用，且能帮助肉芽组织形成。适用于治疗由于锌缺乏引起的肠病性肢端皮炎、口疮、慢性溃疡、结膜炎等。但与青霉胺共用可使后者作用减弱。
  血浆、肝脏、腺胰和骨骼组织是锌的快速交换、储存场所，对日常锌水平的变化很敏感。锌影响动物生长、发育和繁殖功能，影响骨骼和血液的形成及核酸、蛋白质和碳水化合物代谢。与毛的生长、皮肤的健康、创伤的愈合有关。在这些组织上，锌主要与酶结合，作为酶必不可少的组成成分和激活剂。锌是碳酸酐酶胰腺的羧基肽酶、谷氨酸和乳酸脱氢酶等的分子组成成分。可激活尿酸酶、肠液中的二肽酶和其他酶。可通过对垂体、促性腺激素的作用间接对繁殖机能发生作用，一水硫酸锌在饲料中可作为锌元素增补剂。
  

名称

• 中文名: 硫酸锌
• 英文名: zinc sulfate
• 英文别名: Zinc sulphate; Complexonat; zinc(ii) sulfate; Bonazen; Optised; Zinc sulfate solution; Zinc (II) sulfate; zinc,sulfate; EINECS 231-793-3; MFCD00011302; Sulfuric acid zinc salt; White vitriol; Sulfuric acid, zinc salt(1:1); zinc sulfonate; Zinc sulfate anhydrous; Medizinc; Sulfuric acid zinc salt (1:1); zink sulfate; Zinc sulfate

物化性质

• 密度: 1.957
• 沸点: 330ºC at 760 mmHg
• 熔点: 100ºC
• 分子式: O₄SZn
• 分子量: 161.472
• 精确质量: 159.880875
• PSA: 82.98000
• LogP: 0.42550
• 外观性状: 无色固体
• 储存条件: 室温，密封，干燥
• 稳定性:

  1.易溶于水，有吸湿性。加热至680℃时分解为硫酸氧锌Zn3O(SO4)2，750℃以上进一步分解，最后在930℃左右成为氧化锌。

  2.含1个或7个分子的结晶水。无色透明棱形或细小针状晶体或结晶性粗粉。无臭。一水合物超过238℃时失水。七水合物于室温干燥空气中粉化。其水溶液对石蕊呈酸性。溶于水和甘油，几乎不溶于乙醇。

• 水溶解性: H2O: soluble | Soluble
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积88.6

  7.重原子数量:6

  8.表面电荷:0

  9.复杂度:62.2

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：白色粉末。

  2. 密度（g/mL 25ºC）：1.957，无水物，相对密度3.54(25℃)

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：100

  5. 沸点（ºC，常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率（n20/D）：未确定

  8. 闪点（ºC，）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性(mg/mL)：易溶于水，微溶于乙醇、甘油

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZH5260000 CAS REGISTRY NUMBER : 7733-02-0 LAST UPDATED : 199710 DATA ITEMS CITED : 40 MOLECULAR FORMULA : O4-S.Zn MOLECULAR WEIGHT : 161.43 WISWESSER LINE NOTATION : ZN S-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 45 mg/kg/7D-C TOXIC EFFECTS : Cardiac - pulse rate increase, without fall in BP Gastrointestinal - other changes Blood - normocytic anemia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 106 mg/kg TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 180 mg/kg/6W-I TOXIC EFFECTS : Blood - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 3120 mg/kg/43W-I TOXIC EFFECTS : Blood - microcytosis with or without anemia Blood - agranulocytosis Nutritional and Gross Metabolic - changes in metals, not otherwise specified TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 196 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 330 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 69900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29060 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 23300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 66 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 74 mg/kg/3D-I TOXIC EFFECTS : Musculoskeletal - other changes Nutritional and Gross Metabolic - changes in calcium TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1200 mg/kg/60D-C TOXIC EFFECTS : Liver - other changes Nutritional and Gross Metabolic - changes in metals, not otherwise specified TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 7110 mg/kg/4W-I TOXIC EFFECTS : Gastrointestinal - changes in structure or function of endocrine pancreas Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3625 ug/kg/5D-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 333 mg/kg SEX/DURATION : female 1-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 34573 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 15 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 2 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 193 gm/kg SEX/DURATION : female 6-20 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TYPE OF TEST : Micronucleus test MUTATION DATA TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 200 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,193,1979 *** REVIEWS *** TOXICOLOGY REVIEW FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 77220 No. of Facilities: 3067 (estimated) No. of Industries: 52 No. of Occupations: 47 No. of Employees: 40653 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 77220 No. of Facilities: 4755 (estimated) No. of Industries: 52 No. of Occupations: 66 No. of Employees: 89451 (estimated) No. of Female Employees: 27887 (estimated)

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319-H412
• 警示性声明: P273-P280-P305 + P351 + P338-P337 + P313
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): Xi:Irritant
• 风险声明 (欧洲): R41;R50/53
• 安全声明 (欧洲): S26-S39-S61
• 危险品运输编码: UN 3082/9161
• WGK德国: 3
• RTECS号: ZH5260000
• 海关编码: 2833293000

合成路线

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制备

1.将一水硫酸锌ZnSO4·H2O加热至280℃左右使其完全脱水即可生成无水硫酸锌。也可用七水硫酸锌ZnSO4·7H2O为起始物，先在较低的温度下缓慢加热，使其逐步脱水变为一水合物，然后将温度升高至280℃左右。

2.闪锌矿经焙烧后浸提、精炼而得。

3.由硫酸与锌或氧化锌反应而得。

4.主要采用酸解法，以氧化锌或其他含锌化合物为原料，用硫酸分解，再经压滤、浓缩、结晶、分离、烘干而得。

海关

海关编码	2833293000