毒理学数据:
1 、
试验方法：口服
摄入剂量：5690 mg/kg/13W-I
测试对象：啮齿动物-鼠
毒性类型：MutipleDose
毒性作用：1.大脑受影响
2.慢性数据-睾丸重量的变化
2 、
试验方法：口服
摄入剂量：910 mg/kg/26W-I
测试对象：啮齿动物-鼠
毒性类型：MutipleDose
毒性作用：诱导或改变血液或组织水平-其他酶 对皮肤、黏膜有刺激性。无水物及浓溶液可引起皮肤溃疡。吸入粉尘可引起呼吸困难。消化及循环系统功能异常。皮肤接触后，可用2%的碳酸氢钠溶液冲洗。生产和使用硫酸锌的工作人员必须穿戴个人防护用具。
3 、
试验方法：口服
摄入剂量：1680年mg/kg/14D-I
测试对象：啮齿动物-鼠
毒性类型：MutipleDose
毒性作用：慢性数据-死亡
生态学数据:
该物质对环境可能有危害，对水体应给予特别注意。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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ZH1400000
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CHEMICAL NAME :
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Zinc chloride
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CAS REGISTRY NUMBER :
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7646-85-7
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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74
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MOLECULAR FORMULA :
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Cl2-Zn
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MOLECULAR WEIGHT :
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136.27
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WISWESSER LINE NOTATION :
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ZN G2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - child
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DOSE/DURATION :
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169 mg/kg
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - dyspnea Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Skin and Appendages - dermatitis, other (after systemic exposure)
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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4800 mg/m3/30M
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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350 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1960 mg/m3/10M
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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58 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Vascular - BP elevation not characterized in autonomic section Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3690 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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329 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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24 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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330 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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9090 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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11 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
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200 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Intraperitoneal
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
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173 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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910 mg/kg/26W-I
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TOXIC EFFECTS :
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Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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6875 mg/kg/39W-I
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TOXIC EFFECTS :
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Cardiac - EKG changes not diagnostic of specified effects Vascular - BP elevation not characterized in autonomic section Blood - changes in erythrocyte (RBC) count
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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17 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Bird - chicken
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DOSE/DURATION :
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15 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - testicular tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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155 mg/kg
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SEX/DURATION :
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male 33 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male Endocrine - changes in luteinizing hormone Endocrine - changess in gonadotropins
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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30 gm/kg
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SEX/DURATION :
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female 7-8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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20500 ug/kg
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SEX/DURATION :
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female 8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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12500 ug/kg
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SEX/DURATION :
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female 11 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - musculoskeletal system
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravaginal
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DOSE :
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29184 ug/kg
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SEX/DURATION :
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female 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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DNA inhibition
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TYPE OF TEST :
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Cytogenetic analysis
MUTATION DATA
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TYPE OF TEST :
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Morphological transformation
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TEST SYSTEM :
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Rodent - hamster Embryo
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REFERENCE :
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CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,193,1979 *** REVIEWS *** ACGIH TLV-STEL 2 mg/m3, vapor DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1 mg/m3, fume DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 35,165,1975 TOXICOLOGY REVIEW FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 TOXICOLOGY REVIEW PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 12,102,1969 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 1 mg/m3 (fume) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,283,1971 OSHA PEL (Gen Indu):8H TWA 1 mg/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 mg/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 mg/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 mg/m3, fume CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 1 mg/m3 (fume) JAN 1993 OEL-AUSTRALIA:TWA 1 mg/m3;STEL 2 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 1 mg/m3;STEL 2 mg/m3 (fume) JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3 (fume) JAN 1993 OEL-FINLAND:TWA 1 mg/m3 (fume) JAN 1993 OEL-FRANCE:TWA 1 mg/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg/m3 (fume) JAN 1993 OEL-THE PHILIPPINES:TWA 1 mg/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 1 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 1 mg/m3 (fume) JAN 1993 OEL-THAILAND:TWA 1 mg/m3 (fume) JAN 1993 OEL-TURKEY:TWA 1 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg/m3;STEL 2 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ZINC CHLORIDE FUME-air:10H TWA 1 mg/m3;STEL 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 77150 No. of Facilities: 20416 (estimated) No. of Industries: 192 No. of Occupations: 84 No. of Employees: 185570 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 77150 No. of Facilities: 22612 (estimated) No. of Industries: 172 No. of Occupations: 115 No. of Employees: 353004 (estimated) No. of Female Employees: 87750 (estimated)
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