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DL-间酪氨酸

DL-间酪氨酸用途

DL-m-Tyrosine 对拟南芥根系生长有影响。Carbidopa 与 DL-m-Tyrosine 联合用具有有效的降压作用。

DL-间酪氨酸名称

[ CAS 号 ]:
775-06-4

[ 中文名 ]:
DL-间酪氨酸

[ 英文名 ]:
DL-m-Tyrosine

[中文别名 ]:

[英文别名 ]:

DL-M-TYROSINE
EINECS 212-270-9
3-hydroxy-phenylalanine
3-Hydroxy-DL-phenylalanine
DL-3-TYROSINE
D/L-3-hydroxy-phenylalanine
3-Hydroxyphenylalanine
DL-META-TYROSINE
D,L-M-TYR
M-TYROSINE

DL-间酪氨酸生物活性

[ 描述 ]:

DL-m-Tyrosine 对拟南芥根系生长有影响。Carbidopa 与 DL-m-Tyrosine 联合用具有有效的降压作用。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Schuster B, et al. The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8433-7.

[2]. Bertin C, et al. Grass roots chemistry: meta-tyrosine, an herbicidal nonprotein amino acid. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16964-9.

DL-间酪氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
387.2±32.0 °C at 760 mmHg

[ 熔点 ]:
280-285 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₁₁NO₃

[ 分子量 ]:
181.189

[ 闪点 ]:
188.0±25.1 °C

[ 精确质量 ]:
181.073898

[ PSA ]:
83.55000

[ LogP ]:
0.38

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.614

[ 储存条件 ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DL-间酪氨酸MSDS

DL-间酪氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2278000

CHEMICAL NAME :: m-Tyrosine, DL-

CAS REGISTRY NUMBER :: 775-06-4

BEILSTEIN REFERENCE NO. :: 2416853

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H11-N-O3

MOLECULAR WEIGHT :: 181.21

WISWESSER LINE NOTATION :: QVYZ1R CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02549 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 38,251,1976

DL-间酪氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YP2278000

[ 海关编码 ]:
2922509090

DL-间酪氨酸合成路线

DL-间酪氨酸上下游产品

DL-间酪氨酸上游产品

DL-间酪氨酸下游产品

DL-间酪氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

DL-间酪氨酸文献

Pleiotropic physiological consequences of feedback-insensitive phenylalanine biosynthesis in Arabidopsis thaliana.

Plant J. 63(5) , 823-35, (2010)

A large proportion of plant carbon flow passes through the shikimate pathway to phenylalanine, which serves as a precursor for numerous secondary metabolites. To identify new regulatory mechanisms aff...

Concomitant tumor resistance: the role of tyrosine isomers in the mechanisms of metastases control.

Cancer Res. 72(5) , 1043-50, (2012)

Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-d...

Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations.

J. Clin. Endocrinol. Metab. 86(6) , 2899-902, (2001)

ABSTRACT Since glucose intake acutely increases reactive oxygen species (ROS) generation by polymorphonuclear leucocytes (PMN) and mononuclear cells (MNC), we have now investigated whether a fast over...

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