亚硒酸
亚硒酸用途
可用作氧化剂以及制取其他硒化合物,用于制取治疗地方性克山病的有效药物亚硒酸钠
【用途二】
用作化学试剂及还原剂
【用途三】
医药中间体、化学试剂
亚硒酸名称
[ CAS 号 ]:
7783-00-8
[ 中文名 ]:
亚硒酸
[ 英文名 ]:
Selenious acid
[中文别名 ]:
[英文别名 ]:
- Monohydrated selenium dioxide
- Selenium dioxide,monohydrated
- EINECS 231-974-7
- selenic(IV) acid
- seleniums acid
- EINECS 231-957-4
- MFCD00134090
- Selenious acid (H2SeO3)
- selenious acid
亚硒酸物理化学性质
[ 密度 ]:
4.81 g/mL at 25ºC(lit.)
[ 沸点 ]:
684.9ºC(lit.)
[ 熔点 ]:
70ºC
[ 分子式 ]:
H2O3Se
[ 分子量 ]:
128.97400
[ 闪点 ]:
690°C
[ 精确质量 ]:
129.91700
[ PSA ]:
57.53000
[ 外观性状 ]:
powder
[ 储存条件 ]:
Store at RT.
[ 稳定性 ]:
Stable.
[ 水溶解性 ]:
H2O: soluble | 167 g/100 mL (20 ºC)
亚硒酸MSDS
亚硒酸毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VS7175000
- CHEMICAL NAME :
- Selenious acid
- CAS REGISTRY NUMBER :
- 7783-00-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 33
- MOLECULAR FORMULA :
- H2-O3-Se
- MOLECULAR WEIGHT :
- 128.98
- WISWESSER LINE NOTATION :
- H2 SE-O3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg/2D (Continuous)
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,233,1996 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,224,1971 OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84466 No. of Facilities: 345 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 1177 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84466 No. of Facilities: 1294 (estimated) No. of Industries: 17 No. of Occupations: 17 No. of Employees: 7593 (estimated) No. of Female Employees: 1866 (estimated)
亚硒酸安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H331-H373-H410
[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;
[ 风险声明 (欧洲) ]:
R23/25;R33;R50/53
[ 安全声明 (欧洲) ]:
S20/21-S28-S45-S60-S61
[ 危险品运输编码 ]:
UN 2811/2630/3283
[ WGK德国 ]:
3
[ RTECS号 ]:
VS7700000
[ 包装等级 ]:
III
亚硒酸合成路线
亚硒酸上下游产品
亚硒酸上游产品
亚硒酸下游产品
亚硒酸制备
1.室温下,将密度为1.18的试剂硝酸与硒进行反应,直至氮氧化物不再溢出,
然后,将混合于50-60 ºC下蒸发至干。所得固体用水溶解并过滤,滤液蒸发浓缩至原体积的1/4后,冷却结晶,吸滤所得晶体用少量冰水洗涤,洗涤液和滤液合并回收利用,所得结晶经上述方法重结晶,即可得试剂亚硒酸。
2.在瓷皿中将纯净的SeO2溶于少量水中,在水浴上将溶液蒸发浓缩到开始析出结晶(操作过程中应避免灰尘进入,否则会还原为Se)。冷却后将析出的亚硒酸结晶用玻璃砂芯漏斗抽滤,再用水重结晶一次后抽干。将产物放在两层滤纸之间用力挤压,然后在装有KOH的真空干燥器中放置数日使之干燥。若用浓硫酸或五氧化二磷作干燥剂,存放较久则可能进一步脱水变成二氧化硒。
亚硒酸文献
Tissue Eng. Part A 20(23-24) , 3163-75, (2014)
An attractive cell source for cartilage tissue engineering, human adipose-derived stem cells (hASCs) can be easily expanded and signaled to differentiate into chondrocytes. This study explores the inf...
Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models.Clin. Exp. Allergy 44(12) , 1515-24, (2014)
Atopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureu...
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog.Biomed. Pharmacother. 68(8) , 1141-8, (2014)
Sarco/endoplasmic reticulum calcium ATPase (SERCA) enzymes play important roles in several signal transduction pathways that control proliferation, differentiation and apoptosis. Here, we reported tha...
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