磺酰氯

磺酰氯用途

【用途一】
用作测定胺类的试剂，也用于有机合成
【用途二】
用作医药、农药、染料及有机合成中间体
【用途三】
硫酰氯是合成农药丁硫克百威的中间体，是重要的酰氯化剂。
【用途四】
主要用作氯化剂或氯磺化剂，如芳香族化合物的氯化、羧酸的氯化及其他各种有机和无机化合物的氯化。也用于制造医药品、染料、表面活性剂等
【用途五】
用于有机合成、医药、染料、农药等，也用作表面活性剂。
【用途六】
有机合成氯化剂、磺化剂、氯磺化剂。测定芳香族和脂肪族化合物等。

磺酰氯名称

[ CAS 号 ]:
7791-25-5

[ 中文名 ]:
磺酰氯

[ 英文名 ]:
Sulfuryl chloride

[中文别名 ]:

[英文别名 ]:

Sulfuryl chloride
Sulphuryl dichloride
Sulfuryl dichloride
Sulphuryl chloride
EINECS 232-245-6
MFCD00011451
sulfonyl chloride

磺酰氯物理化学性质

[ 密度 ]:
1.667

[ 沸点 ]:
69 ºC

[ 熔点 ]:
-54.1 °C

[ 分子式 ]:
Cl₂O₂S

[ 分子量 ]:
134.970

[ 闪点 ]:
69.1°C

[ 精确质量 ]:
133.899612

[ PSA ]:
42.52000

[ LogP ]:
1.24

[ 外观性状 ]:
无色或淡黄色

[ 蒸汽密度 ]:
4.7 (vs air)

[ 蒸汽压 ]:
147.7±0.1 mmHg at 25°C

[ 折射率 ]:
1.479

[ 储存条件 ]:
库房通风低温干燥,与碱类、食品添加剂分开存放

[ 稳定性 ]:
Reacts violently with water. Incompatible with acids, alcohols, bases, metals, amines, moisture.

[ 水溶解性 ]:
reacts

磺酰氯MSDS

详细MSDS(安全技术说明书)

磺酰氯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WT4870000

CHEMICAL NAME :: Sulfuryl chloride

CAS REGISTRY NUMBER :: 7791-25-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: Cl2-O2-S

MOLECULAR WEIGHT :: 134.96

WISWESSER LINE NOTATION :: S O2-G2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 159 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,62,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ppm/6H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,62,1983 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2850 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(7),9,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4088 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2256 (estimated) No. of Female Employees: 657 (estimated)

磺酰氯安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H335

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 靶器官 ]:
Blood, Central nervous system, Liver

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R14;R34;R40

[ 安全声明 (欧洲) ]:
S26-S45-S36/37-S36/37/39

[ 危险品运输编码 ]:
UN 2927 6.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
WT4870000

[ 包装等级 ]:
I

[ 危险类别 ]:
8

[ 海关编码 ]:
2812101000

磺酰氯合成路线

详细合成路线

磺酰氯上下游产品

磺酰氯上游产品

磺酰氯下游产品

磺酰氯制备

1.氯化法：将干燥的二氧化硫和氯气在活性炭催化剂存在下进行反应，生成的硫酰氯经冷凝，制得硫酰氯成品。其反应式：

2.用活性炭或樟脑为催化剂使二氧化硫与氯气直接反应可制得氯化硫酰：（1）反应管为一至少有6个球的球形冷凝管，在冷凝管的每个球中先填入疏松的玻璃棉达到半满，后在玻璃棉上放上一层颗粒状的活性炭。冷凝管的下端与一吸滤瓶相连，吸滤瓶的支管连接一CaCl2干燥管，以阻挡外界的湿气。反应所用的氯气和二氧化硫从钢瓶中输出，并分别经装有浓硫酸的洗气瓶进行干燥，然后一同进入一储气瓶中混合。当反应管中的空气被驱除干净后，使混合气体从反应管的上部进入，并在反应管外通自来水强烈冷却。当洗气瓶中气体的流速为每秒3～4个气泡时，过20～30min后，即开始有SO2Cl2滴入吸滤瓶中。可用少量SO2Cl2先润湿一下最上面的球中的填充物，以缩短前面的这一段时间。反应生成的产品相当纯净，经一次分馏即可达到要求。（2）反应器为一用冰水冷却的双口烧瓶，其中一口与CaCl2干燥管相连，另一口插入一通至瓶底的气体导入管，此管通过一“T”形管后分别与Cl2和SO2的进气管相连，Cl2和SO2在进入反应装置前都经充分干燥。将10g打碎成粗颗粒的樟脑放在反应瓶中，通入干燥的SO2，直至樟脑饱和了SO2气体成为液体。随后通入Cl2，即被液体吸收，同时液体褪色。当达到饱和后，重新通入SO2，再通入Cl2。当生成约30g SO2Cl2后，即可同时通入Cl2和SO2。当生成的产物达到所需要的量时，可用水浴将SO2Cl2蒸馏出来，第一次蒸馏所得的产物中还含有樟脑，可将其进行仔细地分馏以进一步纯化。精制方法：用樟脑为催化剂制得的硫酰氯含有微量的樟脑，可进行重复蒸馏除去。

磺酰氯海关

[ 海关编码 ]: 2812101000

磺酰氯文献

Trichlorophenol (TCP) sulfonate esters: a selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides.

Chem. Commun. (Camb.) (10) , 1074-6, (2007)

2,4,6-Trichlorophenol (TCP) sulfonate esters undergo effective aminolysis under conventional heating and microwave irradiation; the reactivity of these species is such that chemoselective transformati...

Detection of Infertility-related Neutralizing Antibodies with a Cell-free Microfluidic Method.

Sci. Rep. 5 , 16551, (2015)

The unwanted emergence of neutralizing antibodies (nAbs) against an endogenous or a therapeutic protein can result in deficiency diseases or therapy failure. Here, we developed a cell-free microfluidi...

pH-activated nanoparticles for controlled topical delivery of farnesol to disrupt oral biofilm virulence.

ACS Nano 9(3) , 2390-404, (2015)

Development of effective therapies to control oral biofilms is challenging, as topically introduced agents must avoid rapid clearance from biofilm-tooth interfaces while targeting biofilm microenviron...

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磺酰氯