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BI-6C9

BI-6C9用途

BI-6C9 是一种 BH3 相互作用结构域 (Bid) 抑制剂,可阻止线粒体外膜电位 (MOMP) 和线粒体分裂,并保护细胞免受死亡。

BI-6C9名称

[ CAS 号 ]:
791835-21-7

[ 英文名 ]:
BI-6C9

[英文别名 ]:

BI-6C9

BI-6C9生物活性

[ 描述 ]:

BI-6C9 是一种 BH3 相互作用结构域 (Bid) 抑制剂,可阻止线粒体外膜电位 (MOMP) 和线粒体分裂,并保护细胞免受死亡。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 线粒体代谢

研究领域 >> 神经疾病

[参考文献]

[1]. Grohm J, et al. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 2010 Jul;24(5):831-8.

BI-6C9物理化学性质

[ 密度 ]:
1.368g/cm3

[ 分子式 ]:
C₂₃H₂₅N₃O₄S₂

[ 分子量 ]:
471.59200

[ 精确质量 ]:
471.12900

[ PSA ]:
144.20000

[ LogP ]:
6.25170

[ 折射率 ]:
1.671

[ 储存条件 ]:
-20°C，密闭，干燥

BI-6C9MSDS

详细MSDS(安全技术说明书)

BI-6C9安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

BI-6C9文献

Differential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum.

Alcohol. Clin. Exp. Res. 39(1) , 55-63, (2015)

Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcoho...

Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma.

Invest. New Drugs 33(1) , 1-11, (2015)

The incidence and mortality of hepatocellular carcinoma (HCC) remain high worldwide. Drug screening from natural plants is one of the potential therapeutic approaches on HCC.The antitumor effect of mo...

Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity.

J. Pharmacol. Exp. Ther. 350(2) , 273-89, (2014)

Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell l...

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