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粘菌素甲烷磺酸钠

粘菌素甲烷磺酸钠用途

Colistin methanesulfonate sodium salt对P. aeruginosa 敏感菌类的MIC 值为 4-16 mg/L.

粘菌素甲烷磺酸钠名称

[ CAS 号 ]:
8068-28-8

[ 中文名 ]:
粘杆菌素甲基磺酸钠

[ 英文名 ]:
Colistin methanesulfonate sodium salt

[中文别名 ]:

[英文别名 ]:

Colistrimethate sodium
EINECS 232-516-9
MFCD00130824
Colimycin M
Colistimethate sodium
Sodium colistimethate
Colistin sodium methanesulfonate
Colistimethate

粘菌素甲烷磺酸钠生物活性

[ 描述 ]:

Colistin methanesulfonate sodium salt对P. aeruginosa 敏感菌类的MIC 值为 4-16 mg/L.

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

在相同的MIC倍数下,甲基磺酸粘杆菌素的杀菌能力比粘菌素低。粘菌素和甲磺酸粘菌素都是粘菌素A和B(1)两种成分盐的不均匀混合物,它们在体外可能有不同的活性[1]。

[参考文献]

[1]. Jian Li, et al. In Vitro Pharmacodynamic Properties of Colistin and Colistin Methanesulfonate against Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis. Antimicrob Agents Chemother. 2001 Mar; 45(3): 781–785.

粘菌素甲烷磺酸钠物理化学性质

[ 分子式 ]:
C₅₈H₁₁₅N₁₆Na₅O₂₈S₅

[ 分子量 ]:
1759.898

[ 精确质量 ]:
1758.615845

[ 外观性状 ]:
white to faintly beige

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble10mg/mL

粘菌素甲烷磺酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
2

[ RTECS号 ]:
GH1650000

粘菌素甲烷磺酸钠文献

High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate.

J. Chromatogr. A. 1369 , 52-63, (2014)

Colistin is a last resort's antibacterial treatment in critically ill patients with multi-drug resistant Gram-negative infections. As appropriate colistin exposure is the key for maximizing efficacy w...

Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium.

PLoS ONE 10 , e0142097, (2015)

Exacerbations associated with chronic lung infection with Pseudomonas aeruginosa are a major contributor to morbidity, mortality and premature death in cystic fibrosis. Such exacerbations are treated ...

In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

Antimicrob. Agents Chemother. 45 , 781-785, (2001)

The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmuco...

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粘菌素甲烷磺酸钠

粘菌素甲烷磺酸钠用途

粘菌素甲烷磺酸钠名称

粘菌素甲烷磺酸钠生物活性

粘菌素甲烷磺酸钠物理化学性质

粘菌素甲烷磺酸钠安全信息

粘菌素甲烷磺酸钠文献

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