佛手柑内酯
佛手柑内酯用途
佛手柑内酯名称
[ CAS 号 ]:
484-20-8
[ 中文名 ]:
佛手苷内酯
[ 英文名 ]:
Bergapten
[中文别名 ]:
[英文别名 ]:
- Geralen
- Heraclin
- Bergapten
- EINECS 207-604-5
- 4-MOP
- Bergaptan
- MFCD00010272
- 7H-Furo[3,2-g][1]benzopyran-7-one, 4-methoxy-
- MAJUDIN
- 4-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one
佛手柑内酯生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
CYP[1]
[体外研究]
[体内研究]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
佛手柑内酯物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
412.4±45.0 °C at 760 mmHg
[ 熔点 ]:
190-193 °C(lit.)
[ 分子式 ]:
C12H8O4
[ 分子量 ]:
216.189
[ 闪点 ]:
203.2±28.7 °C
[ 精确质量 ]:
216.042252
[ PSA ]:
52.58000
[ LogP ]:
2.00
[ 外观性状 ]:
白色至灰白色结晶固体
[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C
[ 折射率 ]:
1.635
[ 储存条件 ]:
2-8°C
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents. May be light sensitive.
[ 水溶解性 ]:
水溶性:实际上不溶;可溶于:乙醚;微溶:苯,醇,氯仿
佛手柑内酯MSDS
佛手柑内酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LV1300000
- CHEMICAL NAME :
- 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-methoxy-
- CAS REGISTRY NUMBER :
- 484-20-8
- BEILSTEIN REFERENCE NO. :
- 0019560
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C12-H8-O4
- MOLECULAR WEIGHT :
- 216.20
- WISWESSER LINE NOTATION :
- T C566 DO LVOJ HO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >30 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 9 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 204 gm/kg/52W-I
- TOXIC EFFECTS :
- Behavioral - fluid intake Endocrine - evidence of thyroid hyperfunction Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 800 mg/kg/8D-I
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - food intake (animal) Skin and Appendages - dermatitis, irritative (after systemic exposure)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4368 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 5600 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 6720 mg/kg
- SEX/DURATION :
- female 7-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 900 mg/kg
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 25,302,1995 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,242,1987 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,327,1986 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,242,1987
佛手柑内酯安全信息
[ 符号 ]:
GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H334-H340-H350
[ 警示性声明 ]:
P201-P261-P308 + P313
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
Xi: Irritant;
[ 风险声明 (欧洲) ]:
R43
[ 安全声明 (欧洲) ]:
S36/37
[ 危险品运输编码 ]:
UN 1759
[ WGK德国 ]:
2
[ RTECS号 ]:
LV1300000
[ 海关编码 ]:
2932999099
佛手柑内酯合成路线
佛手柑内酯上下游产品
佛手柑内酯上游产品
佛手柑内酯下游产品
佛手柑内酯海关
[ 海关编码 ]: 2932999099
[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
佛手柑内酯文献
Regul Toxicol Pharmacol 72 , 578-85, (2015)
Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...
Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells.Mol. Cancer 14 , 130, (2015)
Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how B...
[Chemical constituents contained in seeds of Notopterygium franchetii].Zhongguo Zhong Yao Za Zhi 37(7) , 941-5, (2012)
To study the chemical constituents from the seeds of Notopterygium franchetii.Ethanol extracts of seeds N. franchetii were separated and purified by such methods as normal and reversed phase column ch...
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区域:上海市普陀区
价格:
联系人:徐经理
产品详情:佛手柑内酯
公司名:云南西力生物技术股份有限公司
区域:昆明市盘龙区
价格:
¥需询单/5mg
联系人:郑雪平
产品详情:佛手柑内酯
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥398.0/20mg
¥468.0/50mg
¥708.0/250mg
联系人:刘佳
产品详情:佛手柑内酯
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥4169.0/5g
¥1039.0/1g
¥589.0/1g
¥需询单/1g
联系人:李先生
产品详情:5-Methoxypsoralen
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥250.0/20mg
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¥792.0/250mg
¥2277.0/1g
联系人:夏言
产品详情:[Perfemiker]佛手苷内酯,分析对照品,>98%(GC)
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相关化合物
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