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D-泛醇

D-泛醇用途

D-Panthenol 是泛酸的生物活性醇,可导致细胞中辅酶 A 的量增加。

D-泛醇名称

[ CAS 号 ]:
81-13-0

[ 中文名 ]:
D-泛醇

[ 英文名 ]:
Dexpanthenol

[中文别名 ]:

[英文别名 ]:

Dexpanthenol
synapan
Ilopan
Cozyme
Panadon
Urupan
Proleus
D-pantothenyl alcohol
Intrapan
Motilyn

D-泛醇生物活性

[ 描述 ]:

D-Panthenol 是泛酸的生物活性醇,可导致细胞中辅酶 A 的量增加。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Oguz A, et al. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Int Surg. 2015 Apr;100(4):656-61.

[相关活性小分子]

D-泛醇物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
483.6±45.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₉NO₄

[ 分子量 ]:
205.251

[ 闪点 ]:
246.3±28.7 °C

[ 精确质量 ]:
205.131409

[ PSA ]:
89.79000

[ LogP ]:
-0.92

[ 外观性状 ]:
透明无色至略黄色粘性液体

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.502

[ 储存条件 ]:
室温，密封，干燥

D-泛醇MSDS

详细MSDS(安全技术说明书)

D-泛醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES4316000

CHEMICAL NAME :: Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-

CAS REGISTRY NUMBER :: 81-13-0

BEILSTEIN REFERENCE NO. :: 1724947

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C9-H19-N-O4

MOLECULAR WEIGHT :: 205.29

WISWESSER LINE NOTATION :: Q3MVYQX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,43,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 73,292,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 73,292,1950 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80472 No. of Facilities: 1172 (estimated) No. of Industries: 7 No. of Occupations: 16 No. of Employees: 8069 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80472 No. of Facilities: 2510 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 46519 (estimated) No. of Female Employees: 36944 (estimated)

D-泛醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 2583 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
ES4316000

[ 海关编码 ]:
2924199090

D-泛醇合成路线

详细合成路线

D-泛醇上下游产品

D-泛醇上游产品

D-泛醇下游产品

D-泛醇制备

1.将D-泛酸内酯和3-氨基丙醇混合在甲醇中，缩合而成。反应如下：

D-泛醇海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

D-泛醇文献

Release of betaine and dexpanthenol from vitamin E modified silicone-hydrogel contact lenses.

Curr. Eye Res. 40(3) , 267-73, (2015)

To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness.Profiles of the release of osmoprotectant...

Cystoid macular oedema following Descemet membrane endothelial keratoplasty.

Br. J. Ophthalmol. 99(1) , 98-102, (2015)

To determine the incidence and potential risk factors of cystoid macular oedema (CMO) following Descemet membrane endothelial keratoplasty (DMEK) with or without simultaneous cataract surgery.In this ...

Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments.

Lasers Surg. Med. 47(3) , 257-65, (2015)

At present, there is no standardized in vitro human skin model for wound healing. Therefore, our aim was to establish and characterize an in vitro/ex vivo three-dimensional (3D) wound healing model, w...

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