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双琥珀酰亚胺辛二酸酯钠盐

双琥珀酰亚胺辛二酸酯钠盐用途

BS3 Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

双琥珀酰亚胺辛二酸酯钠盐名称

[ CAS 号 ]:
82436-77-9

[ 中文名 ]:
双琥珀酰亚胺辛二酸酯钠盐

[ 英文名 ]:
BS3 Crosslinker

[中文别名 ]:

二(磺基琥珀酸亚酰胺)辛二酸酯

[英文别名 ]:

Bis(sulfosuccinimidyl)suberate(BS3(Sulfo-DSS))
BS(3) Cpd
MFCD00054982
Bis(sulfosuccinimidyl) suberate sodium salt
BSSIS
bis(sulfosuccinimidyl)suberate
Disulfosuccinimidyl suberate

双琥珀酰亚胺辛二酸酯钠盐生物活性

[ 描述 ]:

BS3 Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Non-cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。

[参考文献]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

双琥珀酰亚胺辛二酸酯钠盐物理化学性质

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₁₆H₂₀N₂O₁₄S₂

[ 分子量 ]:
550.447

[ 精确质量 ]:
550.017517

[ PSA ]:
255.69000

[ 外观性状 ]:
powder

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 10 mg/mL

双琥珀酰亚胺辛二酸酯钠盐MSDS

详细MSDS(安全技术说明书)

双琥珀酰亚胺辛二酸酯钠盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

双琥珀酰亚胺辛二酸酯钠盐文献

Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor.

PLoS ONE 10(3) , e0120162, (2015)

Aberrant glycosylation changes normal cellular functions and represents a specific hallmark of cancer. Lewisy (Ley) carbohydrate upregulation has been reported in a variety of cancers, including oral ...

Toll-Like Receptor 9 Alternatively Spliced Isoform Negatively Regulates TLR9 Signaling in Teleost Fish.

PLoS ONE 10 , e0126388, (2015)

Toll-like receptor 9 (TLR9) recognizes and binds unmethylated CpG motifs in DNA, which are found in the genomes of bacteria and DNA viruses. In fish, Tlr9 is highly diverse, with the number of introns...

Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure.

Nucleic Acids Res. 43 , 3033-45, (2015)

Despite insights on the cellular level, the molecular details of chromatin reorganization in sperm development, which involves replacement of histone proteins by specialized factors to allow ultra mos...

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