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辛二酸双(N-羟基琥珀酰亚胺酯)

辛二酸双(N-羟基琥珀酰亚胺酯)用途

DSS Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

辛二酸双(N-羟基琥珀酰亚胺酯)名称

[ CAS 号 ]:
68528-80-3

[ 中文名 ]:
双琥珀酰亚胺辛二酸酯

[ 英文名 ]:
DSS Crosslinker

[中文别名 ]:

[英文别名 ]:

Di(N-succinimidyl) Suberate
Disuccinimidyl octanedioate
Suberic acid bis(N-succinimidyl) ester
MFCD00049059
Disuccinimidyl suberate
Suberic acid bis(N-hydroxysuccinimide ester)

辛二酸双(N-羟基琥珀酰亚胺酯)生物活性

[ 描述 ]:

DSS Crosslinker 是一种不可降解 (non-cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Non-cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。

[参考文献]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

辛二酸双(N-羟基琥珀酰亚胺酯)物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
513.5±60.0 °C at 760 mmHg

[ 熔点 ]:
169-170ºC

[ 分子式 ]:
C₁₆H₂₀N₂O₈

[ 分子量 ]:
368.339

[ 闪点 ]:
264.4±32.9 °C

[ 精确质量 ]:
368.121979

[ PSA ]:
127.36000

[ LogP ]:
-2.24

[ 外观性状 ]:
powder

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
chloroform: 50 mg/mL | Insoluble in water. Soluble in chloroform: 50 mg/mL.

辛二酸双(N-羟基琥珀酰亚胺酯)MSDS

辛二酸双(N-羟基琥珀酰亚胺酯)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29171900

辛二酸双(N-羟基琥珀酰亚胺酯)合成路线

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辛二酸双(N-羟基琥珀酰亚胺酯)文献

Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.

J. Virol. 89(6) , 3256-74, (2015)

Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 plays an essential role in KSHV lytic infection by promoting viral gene expression at the posttranscriptional level. Using bioinformatic and bioche...

Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.

Nat. Commun. 6 , 6123, (2015)

The chaperones Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates containing alpha and beta subunits, except beta7. Here we elucid...

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.

Br. J. Pharmacol. 172(2) , 593-605, (2014)

Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic traffick...

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