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辛二酸

辛二酸用途

Octanedioic acid 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏有关,即丙二醇-羧基酶缺乏症。

辛二酸名称

[ CAS 号 ]:
505-48-6

[ 中文名 ]:
辛二酸

[ 英文名 ]:
Octanedioic acid

[中文别名 ]:

[英文别名 ]:

octanedinoic acid diethyl ester
EINECS 208-010-9
Suberic acid
MFCD00004428
Octandisaeure-diaethylester
Ethyl suberate
SUBERIC ACID DIETHYL ESTER
1,8-diethyl octanedioate
DIETHYL SUBERATE
Korksaeurediaethylester

辛二酸生物活性

[ 描述 ]:

Octanedioic acid 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏有关,即丙二醇-羧基酶缺乏症。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Gregersen N, et al. General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases. Clin Chim Acta. 1983 Aug 15;132(2):181-91.

[相关活性小分子]

辛二酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
361.2±25.0 °C at 760 mmHg

[ 熔点 ]:
140-144 °C(lit.)

[ 分子式 ]:
C₈H₁₄O₄

[ 分子量 ]:
174.194

[ 闪点 ]:
186.5±19.7 °C

[ 精确质量 ]:
174.089203

[ PSA ]:
74.60000

[ LogP ]:
0.80

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.476

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents, bases.

[ 水溶解性 ]:
0.6 g/L (20 ºC)

辛二酸MSDS

辛二酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ 海关编码 ]:
2917190090

辛二酸合成路线

辛二酸上下游产品

辛二酸上游产品

辛二酸下游产品

辛二酸制备

1. 烟草：OR，44；BU，26；合成：由氧化蓖麻油或蓖麻油酸或环辛烷制得。

2.制法：

于装有搅拌器、回流冷凝器的反应瓶中，加入辛二腈（2）136g（1.0mol），50%（质量分数）的硫酸1800mL，搅拌下加热回流10h。冷却后析出固体。过滤，水洗，而后用丙酮重结晶，得辛二酸（1）156g，mp141～142℃，收率90%。

辛二酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

辛二酸文献

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

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辛二酸