綠膿素

綠膿素用途

绿脓杆菌素(Pyocyanine)是一种吩嗪,是由铜绿假单胞菌产生的一种毒性、群体感应(QS)控制的代谢物。绿脓素是一种氧化还原活性化合物,可促进活性氧(ROS)的生成。绿脓杆菌素还具有抗菌特性,并在与其他细菌物种的竞争中提高适应性【1】。

綠膿素名称

[ CAS 号 ]:
85-66-5

[ 中文名 ]:
綠膿素

[ 英文名 ]:
Pyocyanine

[英文别名 ]:

Sanasin
Phenazinium, 1-hydroxy-5-methyl-, inner salt
5-methyl-5H-phenazin-1-one
Pyocyanin
1-hydroxy-5-methyl-phenazinium betaine
5-Methylphenazin-5-ium-1-olate
5-methylphenazin-1(5H)-one
Sanazin
1(5H)-phenazinone, 5-methyl-
Pyocyanine

綠膿素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Paulina Castañeda-Tamez, et al. Pyocyanin Restricts Social Cheating in Pseudomonas aeruginosa. Front Microbiol. 2018 Jun 27;9:1348.

綠膿素物理化学性质

[ 密度 ]:
1.24g/cm3

[ 沸点 ]:
403.3ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₀N₂O

[ 分子量 ]:
210.231

[ 闪点 ]:
197.7ºC

[ 精确质量 ]:
210.079315

[ PSA ]:
39.83000

[ LogP ]:
2.35630

[ 折射率 ]:
1.665

[ 储存条件 ]:
-20°C，密闭，干燥

綠膿素MSDS

綠膿素安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

綠膿素合成路线

綠膿素上下游产品

綠膿素上游产品

綠膿素下游产品

綠膿素海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

綠膿素文献

Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.

PLoS ONE 10(4) , e0124961, (2015)

Oxidative stress enhances inflammation and reduces the effectiveness of corticosteroids, but the inflammatory signalling pathways induced by oxidants remain ill-defined. Phosphorylation of histone 3 a...

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.

PLoS Pathog. 11 , e1004946, (2015)

Pseudomonas aeruginosa infection can be disastrous in chronic lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease. Its toxic effects are largely mediated by secreted virule...

The impact of plant volatiles on bacterial quorum sensing.

Lett. Appl. Microbiol. 60(1) , 8-19, (2015)

Studies describing the use of essential oil constituents as antimicrobial agents have steadily increased; however, some phyto-constituents are often overlooked due to unfavourable minimum inhibitory c...

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綠膿素