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N-甲基邻氨基苯甲酸甲酯

N-甲基邻氨基苯甲酸甲酯用途

N-甲基邻氨基苯甲酸甲酯是一种萜烯,是一种辛辣的化合物,可以在柑橘网状白杨叶中找到。N-甲基邻氨基苯甲酸甲酯具有疼痛研究的潜力[1]。

N-甲基邻氨基苯甲酸甲酯名称

[ CAS 号 ]:
85-91-6

[ 中文名 ]:
邻甲氨基苯甲酸甲酯

[ 英文名 ]:
methyl n-methylanthranilate

[中文别名 ]:

[英文别名 ]:

Methyl 2-(methylamino)benzoate
methyl n-methylanthranilate
Benzoic acid, 2-(methylamino)-, methyl ester
EINECS 201-642-6
MFCD00017183

N-甲基邻氨基苯甲酸甲酯生物活性

[ 描述 ]:

N-甲基邻氨基苯甲酸甲酯是一种萜烯,是一种辛辣的化合物,可以在柑橘网状白杨叶中找到。N-甲基邻氨基苯甲酸甲酯具有疼痛研究的潜力[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Correa E, et, al. Methyl-N-methylanthranilate, a pungent compound from Citrus reticulata Blanco leaves. Pharm Biol. 2016;54(4):569-71.

N-甲基邻氨基苯甲酸甲酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
252.4±13.0 °C at 760 mmHg

[ 熔点 ]:
17-19 °C(lit.)

[ 分子式 ]:
C₉H₁₁NO₂

[ 分子量 ]:
165.189

[ 闪点 ]:
106.5±19.8 °C

[ 精确质量 ]:
165.078979

[ PSA ]:
38.33000

[ LogP ]:
2.69

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
室温

N-甲基邻氨基苯甲酸甲酯MSDS

N-甲基邻氨基苯甲酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB3500000

CHEMICAL NAME :: Anthranilic acid, N-methyl-, methyl ester

CAS REGISTRY NUMBER :: 85-91-6

BEILSTEIN REFERENCE NO. :: 0607217

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: 1OVR BM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3380 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - changes in motor activity (specific assay) Behavioral - analgesia

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,359,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07000 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7380 mg/kg/90D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 8,359,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1823 No. of Facilities: 738 (estimated) No. of Industries: 12 No. of Occupations: 14 No. of Employees: 6529 (estimated) No. of Female Employees: 2515 (estimated)

N-甲基邻氨基苯甲酸甲酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S36/37/39-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
CB3500000

[ 海关编码 ]:
2922499990

N-甲基邻氨基苯甲酸甲酯合成路线

N-甲基邻氨基苯甲酸甲酯上下游产品

N-甲基邻氨基苯甲酸甲酯上游产品

N-甲基邻氨基苯甲酸甲酯下游产品

N-甲基邻氨基苯甲酸甲酯制备

【方法一】
由邻氨基苯甲酸甲酯甲基化而得。
由N-甲基代邻氨基苯甲酸与甲醇酯化而成。
【方法二】
将25.1g二（甲硫基）甲烷溶于50ml冰乙酸，冷却下加入26.5ml30%过氧化氢，在室温搅拌0.5h后加入300ml二氯甲烷，并加入60g碳酸钾中和乙酸，过滤，滤液用无水硫酸钠干燥，蒸除溶剂，减压分馏，得22.4g成品，收率86%。

N-甲基邻氨基苯甲酸甲酯海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

N-甲基邻氨基苯甲酸甲酯文献

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Regul Toxicol Pharmacol 72 , 578-85, (2015)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic in...

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