GLP-GLU-PRO-NH2: GLP-EP-NH2

GLP-GLU-PRO-NH2: GLP-EP-NH2用途

(Glu2)-TRH是促甲状腺素释放激素(TRH；HY-P0002)的代谢稳定类似物,是小鼠大脑中TRH胆碱能效应的负调节剂。(Glu2)-TRH显著减弱TRH诱导的海马细胞外乙酰胆碱释放。(Glu2)-TRH不被甲状腺解放酶代谢。(Glu2)-TRH在中枢神经系统中表现出神经保护、抗抑郁、抗惊厥作用[1]。

GLP-GLU-PRO-NH2: GLP-EP-NH2名称

[ CAS 号 ]:
85541-78-2

[ 中文名 ]:
GLP-GLU-PRO-NH2: GLP-EP-NH2

[ 英文名 ]:
[Glu2]-TRH

[中文别名 ]:

(GLU2)-TRH

[英文别名 ]:

GLP-GLU-PRO-NH2
PE-E-P-NH2
fertilization promoting peptide
FPP
(GLU2)-TRH
PYR-GLU-PRO-NH2
PGLU-GLU-PRO AMIDE
PYROGLU-GLU-PRO AMIDE
FPP,Fertilization-ProMoting Peptide
pyroglutamyl-glutamyl-prolineamide

GLP-GLU-PRO-NH2: GLP-EP-NH2生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 甲状腺激素受体

研究领域 >> 神经疾病

[体内研究]

(Glu2)-TRH(1-100μmol/kg；静脉注射) 剂量依赖性地减弱 TRH公司诱导的兴奋作用[1]。 (Glu2)-TRH(10μmol/kg；静脉注射) 在戊巴比妥 (60 mg/kg；腹腔) 前 10分钟给药,与载体治疗组相比,睡眠时间减少了大约 20%[1]。动物模型：雄性Swiss Webster小鼠(30 g)[1]剂量：1、2、5、10、15、25、50、100μmol/kg给药：IV；戊巴比妥(60 mg/kg,i.p.)前10分钟结果：剂量依赖性地减弱TRH诱导的(10μmol/kg；iv)兴奋作用。

[参考文献]

[1]. Vien Nguyen, et al. [Glu2]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice. Brain Res Bull. 2010 Apr 29;82(1-2):83-6.

GLP-GLU-PRO-NH2: GLP-EP-NH2物理化学性质

[ 密度 ]:
1.416g/cm3

[ 沸点 ]:
899.9ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₂₂N₄O₆

[ 分子量 ]:
354.35800

[ 闪点 ]:
498ºC

[ 精确质量 ]:
354.15400

[ PSA ]:
158.90000

[ 折射率 ]:
1.575

GLP-GLU-PRO-NH2: GLP-EP-NH2MSDS

详细MSDS(安全技术说明书)

GLP-GLU-PRO-NH2: GLP-EP-NH2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

GLP-GLU-PRO-NH2: GLP-EP-NH2文献

Fertilization promoting peptide--a possible regulator of sperm function in vivo.

Vitam. Horm. 63 , 1-28, (2001)

Fertilization promoting peptide (FPP), a tripeptide related to thyrotrophin releasing hormone (TRH), is found in seminal plasma. Recent evidence obtained in vitro suggests that FPP may play an importa...

Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner.

Mol. Reprod. Dev. 57(4) , 384-92, (2000)

Fertilization promoting peptide (FPP) and adenosine have been shown to act as first messengers, regulating availability of the second messenger cAMP by initially stimulating cAMP production in uncapac...

In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP).

Peptides 22(12) , 2091-7, (2001)

EEP is a tripeptide structurally similar to thyrotropin releasing hormone (TRH) and, like TRH, it is found in the mammalian brain. TRH has been found to increase in brain regions after seizures and to...

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