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苯酞

苯酞用途

Phthalide 是一种有前途的化学支架,具有强大的抗炎功效。Phthalide 可用于合成多种邻苯二甲酸酯衍生物,包括抗炎剂,抗菌剂,抗氧化剂。

苯酞名称

[ CAS 号 ]:
87-41-2

[ 中文名 ]:
苯酞

[ 英文名 ]:
Phthalide

[中文别名 ]:

[英文别名 ]:

1-Isobenzofuranone
Rabcide
EINECS 201-744-0
1(3H)-4,5,6,7-tetrachloroisobenzofuranone
Fthalide
3-oxo-1,3-dihydro-isobenzofuran
MFCD00005906
5-17-10-00007 (Beilstein Handbook Reference)
1(3H)-Isobenzofuranone
isobenzofuran-1-one

苯酞生物活性

[ 描述 ]:

Phthalide 是一种有前途的化学支架,具有强大的抗炎功效。Phthalide 可用于合成多种邻苯二甲酸酯衍生物,包括抗炎剂,抗菌剂,抗氧化剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Liu Zeng Chen, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. Eur J Med Chem. 2020 Nov 15;206:112722.

[2]. Chakapong Intaraudom, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353.

[3]. Xin Fang, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. J Asian Nat Prod Res. 2020 Dec;22(12):1176-1187.

苯酞物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
290.0±0.0 °C at 760 mmHg

[ 熔点 ]:
71-74 °C(lit.)

[ 分子式 ]:
C₈H₆O₂

[ 分子量 ]:
134.132

[ 闪点 ]:
124.8±22.2 °C

[ 精确质量 ]:
134.036774

[ PSA ]:
26.30000

[ LogP ]:
0.99

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
存放于惰性气体之中;避免光,湿气 (吸湿)

[ 水溶解性 ]:
sparingly soluble

苯酞MSDS

苯酞毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3520000

CHEMICAL NAME :: Phthalide

CAS REGISTRY NUMBER :: 87-41-2

BEILSTEIN REFERENCE NO. :: 0114632

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H6-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,25,1953

苯酞安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TI3520000

[ 海关编码 ]:
29322980

苯酞合成路线

苯酞上下游产品

苯酞上游产品

苯酞下游产品

苯酞制备

1. 烟草：BU，14；FC，9；FC，OR，BU，18。

2.制法：

于装有搅拌器、回流冷凝器、温度计的反应瓶中，加入水130mL，浓硫酸160mL。搅拌下加热至145～150℃。慢慢加入邻氰基苄基氯（2）153g（1mol）反应中有氯化氢逸出。加完后于160℃反应2h。稍冷后倒入烧杯中，自然冷却，析出固体。抽滤，用水充分浸泡以除去无机盐，再抽滤、水洗，干燥，得苯酞（1）120g。用乙醇重结晶，得纯品（1）83g，mp73～75℃，收率71%。

苯酞海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苯酞文献

Development of an Immunosensor for Determination of the Fungicide Chlorothalonil in Vegetables, Using Surface Plasmon Resonance.

J. Agric. Food Chem. 63 , 6325-30, (2015)

An immunosensor based on surface plasmon resonance (SPR-sensor) was developed to analyze chlorothalonil residues and maximum residue limits (MRLs; 0.5-50 mg/kg) in vegetables in Japan. Conjugates of N...

Palladium-catalyzed cascade aryl addition/intramolecular lactonization of phthalaldehyde to access 3-aryl- and alkenylphthalides.

J. Org. Chem. 75(17) , 6043-5, (2010)

A palladium-catalyzed addition of arylboronic acids to phthalaldehyde, followed by an intramolecular lactonization to access 3-substituted phthalides, is described. The procedure tolerates a series of...

Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists.

Bioorg. Med. Chem. 20(16) , 4954-61, (2012)

On the basis of a marine fungal phthalide (paecilocin A) skeleton, we synthesized 20 analogs and evaluated them for peroxisome proliferator-activated receptor gamma (PPAR-γ) binding and activation. Am...

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苯酞