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Neuromedin B.

Neuromedin B.用途

Neuromedin B 是一种含10个氨基酸的神经肽，属于蛙肽家族，为铃蟾肽相关肽。

Neuromedin B.名称

[ CAS 号 ]:
87096-84-2

[ 中文名 ]:
GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2

[ 英文名 ]:
Neuromedin B trifluoroacetate salt

[英文别名 ]:

GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
NEUROMEDIN B,PORCINE
GNLWATGHFM-NH2
H-GLY-ASN-LEU-TRP-ALA-THR-GLY-HIS-PHE-MET-NH2
NEUROMEDIN B,PORCINE MAMMALIAN BOMBESIN-LI
neuromedin-B
Neuromedin B

Neuromedin B.生物活性

[ 描述 ]:

Neuromedin B 是一种含10个氨基酸的神经肽,属于蛙肽家族,为铃蟾肽相关肽。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

多肽产品

[体外研究]

用于刺激大鼠子宫平滑肌收缩的效力(用作分离Neuromedin B(NMB)的生物测定法)与Bombesin(BN)进行比较。以BN为100,以摩尔计算的相对效力对于GRP为48％,对于NMB为4.9％。 NMB对大鼠胃条也具有收缩活性,但效力(引起50％最大反应所需的肽浓度比; EC50)仅为BN的5％(NMB的ECN = EC50)和约10％的GRP( NMB的GRP/EC50的EC50)[1]。

[体内研究]

NMB和GRP对野生型和NMB-R缺陷小鼠眼底平滑肌收缩的影响,野生型小鼠和NMB-的ED50分别为14.4±2.3(n = 8)和10.9±2.3(n = 8) R缺陷小鼠分别为[1]。

[参考文献]

[1]. Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.

[相关活性小分子]

Neuromedin B.物理化学性质

[ 密度 ]:
1.337 g/cm3

[ 沸点 ]:
1697.4ºC

[ 分子式 ]:
C₅₂H₇₃N₁₅O₁₂S

[ 分子量 ]:
1132.29000

[ 闪点 ]:
980.3ºC

[ 精确质量 ]:
1131.53000

[ PSA ]:
464.10000

[ LogP ]:
2.05180

[ 折射率 ]:
1.613

[ 储存条件 ]:
-20°C

Neuromedin B.安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

Neuromedin B.文献

Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice.

Endocrinology 155(7) , 2492-9, (2014)

The hypothalamic-pituitary-adrenal (HPA) axis is a major part of the neuroendocrine system that controls responses to stress, and has an important function in the regulation of various body processes....

Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts.

J. Endocrinol. 217(2) , 141-50, (2013)

Neuromedin B (NMB) is a mammalian bombesin-like peptide that regulates exocrine/endocrine secretion, smooth muscle contraction, body temperature, and the proliferation of some cell types. Here, we sho...

Effect of potential on temperature-dependent SERS spectra of neuromedin B on Cu electrode.

Phys. Chem. Chem. Phys. 15(3) , 807-15, (2013)

Adsorption of decapeptide neuromedin B (NMB) on copper electrode has been investigated by in situ surface-enhanced Raman scattering (SERS) spectroelectrochemistry in the temperature interval from 12 t...

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