4-Deoxypyridoxine 5'-phosphate

4-Deoxypyridoxine 5'-phosphate用途

4-Deoxypyridoxine 5'-phosphate 是一种 Pyridoxal 5'-phosphate 的类似物,也是一种鞘氨醇1-磷酸酯 (S1P) 抑制剂。4-Deoxypyridoxine 5'-phosphate 抑制鸟氨酸脱羧酶 (ornithine decarboxylase) 活性,Ki 为 60 μM。4-Deoxypyridoxine 5'-phosphate 是 Pyridoxal 5'-phosphate 激活谷氨酸脱羧酶 (glutamate apodecarboxylase) 的竞争性抑制剂 (Ki 为 0.27 μM),并强烈抑制谷氨酸依赖于谷氨酸脱羧酶的标记。

4-Deoxypyridoxine 5'-phosphate名称

[ CAS 号 ]:
883-84-1

[ 英文名 ]:
4-Deoxypyridoxine 5'-phosphate

[英文别名 ]:

1ggn
vitamin B-6
PLR
Deoxypyridoxine-P
4-Deoxypyridoxine 5'-phosphate
4-Desoxy-pyridoxol-phosphat
4-Deoxypyridoxin-5'-phosphat

4-Deoxypyridoxine 5'-phosphate生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体

研究领域 >> 代谢疾病

[ 靶点 ]

Sphingosine 1-phosphate (S1P)[1] Ornithine decarboxylase[2] Glutamate apodecarboxylase[3]

[参考文献]

[1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216.

[2]. M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9.

[3]. D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32.

4-Deoxypyridoxine 5'-phosphate物理化学性质

[ 密度 ]:
1.499g/cm3

[ 沸点 ]:
567.6ºC at 760 mmHg

[ 分子式 ]:
C₈H₁₂NO₅P

[ 分子量 ]:
233.15800

[ 闪点 ]:
297.1ºC

[ 精确质量 ]:
233.04500

[ PSA ]:
109.69000

[ LogP ]:
1.01330

[ 折射率 ]:
1.59

[ 储存条件 ]:
2-8°C，干燥，密封

4-Deoxypyridoxine 5'-phosphate安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933399090

4-Deoxypyridoxine 5'-phosphate合成路线

详细合成路线

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4-Deoxypyridoxine 5'-phosphate海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%