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(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐用途

盐酸普瑞拉莫尔((-)-3-聚丙烯盐酸盐)是一种选择性多巴胺自身受体激动剂。盐酸普瑞拉莫尔具有研究精神分裂症的潜力[1][2]。

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐名称

[ CAS 号 ]:
88768-67-6

[ 中文名 ]:
(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐

[ 英文名 ]:
PRECLAMOL HYDROCHLORIDE

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐生物活性

[ 描述 ]:

盐酸普瑞拉莫尔((-)-3-聚丙烯盐酸盐)是一种选择性多巴胺自身受体激动剂。盐酸普瑞拉莫尔具有研究精神分裂症的潜力[1][2]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Seth-Olov Thorberg, et al. Large scale synthesis and absolute configuration of (-)-3-ppp, a selective dopamine autoreceptor agonist. Tetrahedron. 1985, 41(1): 129-139.

[2]. Tamminga CA, et al. Pharmacologic properties of (-)-3PPP (preclamol) in man. J Neural Transm Gen Sect. 1992;88(3):165-75.

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐物理化学性质

[ 沸点 ]:
342.2ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₂₂ClNO

[ 分子量 ]:
255.78

[ 闪点 ]:
158ºC

[ 精确质量 ]:
255.13900

[ PSA ]:
23.47000

[ LogP ]:
3.72150

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐MSDS

详细MSDS(安全技术说明书)

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933399090

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶盐酸盐文献

Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP.

Psychopharmacology 81 , 89-99, (1983)

The two enantiomers of the putative centrally acting dopamine (DA) autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP (Hjorth et al. 1981), were pharmacologically evaluated. An exten...

Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers.

Psychopharmacology 81 , 199-207, (1983)

The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers...

(+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)-piperidine binding to sigma receptors in mouse brain in vivo.

Eur. J. Pharmacol. 161 , 263-266, (1989)

Binding of i.v. administered (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H]3-PPP) in the brain of intact mice is antagonized dose responsively by sigma receptor ligands. The correlation of p...

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