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N6-2-(4-氨基苯基)乙基腺苷

N6-2-(4-氨基苯基)乙基腺苷用途

N6-[2-(4-Aminophenyl)ethyl]adenosine是有效的,非选择性A3腺苷受体激动剂。

N6-2-(4-氨基苯基)乙基腺苷名称

[ CAS 号 ]:
89705-21-5

[ 中文名 ]:
2-(4-氨基苯基)乙基腺苷-5'-羧酸

[ 英文名 ]:
N6-[2-(4-Aminophenyl)ethyl]adenosine

[英文别名 ]:

apnea
N6-[2-(4-Aminophenyl)ethyl]adenosine

N6-2-(4-氨基苯基)乙基腺苷生物活性

[ 描述 ]:

N6-[2-(4-Aminophenyl)ethyl]adenosine是有效的,非选择性A3腺苷受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

研究领域 >> 神经疾病

[参考文献]

[1]. Borowicz KK, et al. N6-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive activity of antiepileptic drugs. Eur J Pharmacol. 1997 May 30;327(2-3):125-133.

[2]. Borowicz KK, et al. N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats. Eur Neuropsychopharmacol. 2000 Jul;10(4):237-243.

[相关活性小分子]

N6-2-(4-氨基苯基)乙基腺苷物理化学性质

[ 密度 ]:
1.65g/cm3

[ 沸点 ]:
781.8ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₂N₆O₄

[ 分子量 ]:
386.40500

[ 闪点 ]:
426.6ºC

[ 精确质量 ]:
386.17000

[ PSA ]:
151.57000

[ LogP ]:
0.32880

[ 折射率 ]:
1.775

[ 储存条件 ]:
-20°C，密闭，干燥

N6-2-(4-氨基苯基)乙基腺苷MSDS

详细MSDS(安全技术说明书)

N6-2-(4-氨基苯基)乙基腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

N6-2-(4-氨基苯基)乙基腺苷合成路线

详细合成路线

N6-2-(4-氨基苯基)乙基腺苷上下游产品

N6-2-(4-氨基苯基)乙基腺苷上游产品

N6-2-(4-氨基苯基)乙基腺苷下游产品

N6-2-(4-氨基苯基)乙基腺苷文献

Adenosine receptor subtypes.

Trends Pharmacol. Sci. 21 , 360-366, (1993)

The numerous and widespread effects of adenosine provide both an opportunity for the development of novel therapeutic agents acting via adenosine receptors and the challenge of achieving selectivity o...

Adenosine A3 receptors mediate hypotension in the angiotensin II-supported circulation of the pithed rat.

Br. J. Pharmacol. 109 , 3-5, (1993)

The cardiovascular effects of N6-2-(4-aminophenyl)ethyladenosine (APNEA), which when radiolabelled with 125I shows high affinity for the newly described adenosine A3 receptor, have been investigated i...

Adenosine A3 receptors: two into one won't go.

Trends Pharmacol. Sci. 14 , 290, (1993)

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