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beta-鼠李素

beta-鼠李素用途

Rhamnetin 是芫荽中的一种槲皮素衍生物,可抑制分泌型磷脂酶 A2 (phospholipase A2) 的活性,具有抗氧化、抗炎的活性。

beta-鼠李素名称

[ CAS 号 ]:
90-19-7

[ 中文名 ]:
鼠李素

[ 英文名 ]:
beta-Rhamnocitrin

[中文别名 ]:

[英文别名 ]:

MFCD00016931
7-O-Methyl Quercetin
EINECS 201-974-1

beta-鼠李素生物活性

[ 描述 ]:

Rhamnetin 是芫荽中的一种槲皮素衍生物,可抑制分泌型磷脂酶 A2 (phospholipase A2) 的活性,具有抗氧化、抗炎的活性。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 炎症/免疫

[参考文献]

[1]. Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9).

beta-鼠李素物理化学性质

[ 密度 ]:
1.634g/cm3

[ 沸点 ]:
627.9ºC at 760 mmHg

[ 熔点 ]:
293-296°C (dec.)

[ 分子式 ]:
C₁₆H₁₂O₇

[ 分子量 ]:
316.26200

[ 闪点 ]:
238.9ºC

[ 精确质量 ]:
316.05800

[ PSA ]:
120.36000

[ LogP ]:
2.29100

[ 外观性状 ]:
黄色粉末

[ 折射率 ]:
1.74

[ 储存条件 ]:
2-8°C

beta-鼠李素MSDS

beta-鼠李素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8748000

CHEMICAL NAME :: Flavone, 7-methoxy-3,3',4',5-tetrahydroxy-

CAS REGISTRY NUMBER :: 90-19-7

BEILSTEIN REFERENCE NO. :: 0047741

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H12-O7

MOLECULAR WEIGHT :: 316.28

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& DQ GQ IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 166 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

beta-鼠李素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LK8748000

beta-鼠李素合成路线

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beta-鼠李素文献

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

[Non-alkaloid chemical constituents from Coptis chinensis].

Zhongguo Zhong Yao Za Zhi 37(9) , 1241-4, (2012)

To separate and identify chemical constituents from Coptis chinensis.The compounds were separated and purified by various chromatographic techniques. Their structures were identified on the basis of t...

Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H₂O₂-induced apoptosis.

J. Ethnopharmacol. 153(3) , 552-60, (2014)

Many studies have emphasized that flavonoids, found in various fruits, vegetables, and seeds, as well as tea and red wine, have potential health-promoting and disease-preventing effects. Rhamnetin is ...

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