(2-苯基丁酰基)脲
(2-苯基丁酰基)脲用途
苯巴比妥的脱羧产物苯乙脲(乙基苯乙酰胺,M 551)可用于预防精神运动性癫痫[1]。
(2-苯基丁酰基)脲名称
[ CAS 号 ]:
90-49-3
[ 中文名 ]:
苯丁酰脲
[ 英文名 ]:
Pheneturide
[中文别名 ]:
[英文别名 ]:
- Lircapyl
- Phenuride
- ETHYLPHENACEMIDE
- PBU
- EINECS 201-998-2
- S 46
- PHENETURIDE
- Benuride
- MFCD00069050
(2-苯基丁酰基)脲生物活性
(2-苯基丁酰基)脲物理化学性质
[ 密度 ]:
1.15g/cm3
[ 熔点 ]:
149.5 °C
[ 分子式 ]:
C11H14N2O2
[ 分子量 ]:
206.24100
[ 精确质量 ]:
206.10600
[ PSA ]:
72.19000
[ LogP ]:
2.46630
[ 折射率 ]:
1.547
[ 储存条件 ]:
2-8°C， 密封， 干燥
(2-苯基丁酰基)脲MSDS
(2-苯基丁酰基)脲毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YU1225000
- CHEMICAL NAME :
- Urea, (2-phenylbutyryl)-
- CAS REGISTRY NUMBER :
- 90-49-3
- LAST UPDATED :
- 199309
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C11-H14-N2-O2
- MOLECULAR WEIGHT :
- 206.27
- WISWESSER LINE NOTATION :
- ZVMVY2&R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2063 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,524,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 910 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,114,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 312 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,641,1967
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 91,437,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 641 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 91,437,1952
(2-苯基丁酰基)脲安全信息
[ 危害码 (欧洲) ]:
Xi
[ 危险品运输编码 ]:
UN 3249
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
(2-苯基丁酰基)脲合成路线
(2-苯基丁酰基)脲上下游产品
(2-苯基丁酰基)脲上游产品
(2-苯基丁酰基)脲下游产品
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