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4,4'-二(N,N-二甲氨基)二苯甲酮

4,4'-二(N,N-二甲氨基)二苯甲酮用途

【用途一】
用作碱性染料的重要中间体
【用途二】
用作测定钨的试剂、染料中间体及光刻制板用增感剂
【用途三】
米氏酮是碱性染料的重要中间体，用于碱性艳蓝B、碱性艳蓝R等的生产。
【用途四】
测定钨。金属有机化合物定性试验。制造染料。

4,4'-二(N,N-二甲氨基)二苯甲酮名称

[ CAS 号 ]:
90-94-8

[ 中文名 ]:
米氏酮

[ 英文名 ]:
Michler's ketone

[中文别名 ]:

[英文别名 ]:

4,4'-Bis(dimethylamino)benzophenone
Bis[p-(N,N-dimethylamino)phenyl] ketone
EINECS 202-027-5
Methanone, bis[4- (dimethylamino)phenyl]-
Methanone, bis[4-(dimethylamino)phenyl]-
Bis[4-(dimethylamino)phenyl]methanone
Michler's ketone
MFCD00008312

4,4'-二(N,N-二甲氨基)二苯甲酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
427.7±30.0 °C at 760 mmHg

[ 熔点 ]:
174 -176 °C(lit.)

[ 分子式 ]:
C₁₇H₂₀N₂O

[ 分子量 ]:
268.353

[ 闪点 ]:
183.9±16.9 °C

[ 精确质量 ]:
268.157562

[ PSA ]:
23.55000

[ LogP ]:
3.87

[ 外观性状 ]:
白色至淡绿色晶体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
室温，密封

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.

[ 水溶解性 ]:
400 mg/L (20 ºC)

4,4'-二(N,N-二甲氨基)二苯甲酮MSDS

4,4'-二(N,N-二甲氨基)二苯甲酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ0250000

CHEMICAL NAME :: Benzophenone, 4,4'-bis(dimethylamino)-

CAS REGISTRY NUMBER :: 90-94-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C17-H20-N2-O

MOLECULAR WEIGHT :: 268.39

WISWESSER LINE NOTATION :: 1N1&R D- 2V

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1500 ug/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,17,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1044 No. of Facilities: 174 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 2026 (estimated) No. of Female Employees: 405 (estimated)

4,4'-二(N,N-二甲氨基)二苯甲酮安全信息

[ 符号 ]:

GHS05, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318-H341-H350

[ 警示性声明 ]:
P201-P280-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R41;R45;R68

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DJ0250000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2922399090

4,4'-二(N,N-二甲氨基)二苯甲酮合成路线

4,4'-二(N,N-二甲氨基)二苯甲酮上下游产品

4,4'-二(N,N-二甲氨基)二苯甲酮上游产品

4,4'-二(N,N-二甲氨基)二苯甲酮下游产品

4,4'-二(N,N-二甲氨基)二苯甲酮制备

由N,N-二甲基苯胺与光气缩合而得。

4,4'-二(N,N-二甲氨基)二苯甲酮海关

[ 海关编码 ]: 2922399090

[ 中文概述 ]:
2922399090 其他氨基醛、氨基酮及其盐（包括氨基醌及其盐，但含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4,4'-二(N,N-二甲氨基)二苯甲酮文献

Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment.

Environ. Sci. Technol. 41(9) , 3269-76, (2007)

Bioaccumulation in fish depends on the dynamics of various processes that involve fish uptake, storage, and elimination of xenobiotics. Elimination via fish biotransformation is a primary process that...

A comparison of the mutagenicity and macromolecular binding of the carcinogens Michler's ketone and reduced Michler's ketone.

Mutat. Res. 119(1) , 7-14, (1983)

The mutagenicity of 4,4'-bis(dimethylamino)benzophenone (Michler's ketone, MK, CAS No. 90-94-8) and 4,4'-methylenebis(N,N-dimethyl)benzamine (reduced Michler's ketone, RMK, CAS No. 101-61-1) for Salmo...

Michler's ketone.

Rep. Carcinog. 12 , 270-1, (2011)

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