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肌酸激酶

肌酸激酶用途

肌酸激酶催化肌酸和ATP的可逆反应,形成磷酸肌酸和ADP。肌酸激酶是在快速能量转换期间维持恒定ATP/ADP比率的关键酶[1]。

肌酸激酶名称

[ CAS 号 ]:
9001-15-4

[ 中文名 ]:
肌氨酸激酶 (磷酸化)

[ 英文名 ]:
ec 2.7.3.2

[中文别名 ]:

[英文别名 ]:

EINECS 232-585-5
atp: creatine n-phosphotransferase type iv
creatine kinase type iii
MFCD00130876
ck
creatine kinase type i
atp: creatine n-phosphotransferase type i
atp: creatine n-phosphotransferase type iii
atp: creatine n-phosphotransferase
cpk

肌酸激酶生物活性

[ 描述 ]:

肌酸激酶催化肌酸和ATP的可逆反应,形成磷酸肌酸和ADP。肌酸激酶是在快速能量转换期间维持恒定ATP/ADP比率的关键酶[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. McLeish MJ, et al. Relating structure to mechanism in creatine kinase. Crit Rev Biochem Mol Biol. 2005 Jan-Feb;40(1):1-20.

肌酸激酶物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
629.9±55.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₁₂Cl₂N₂O₆

[ 分子量 ]:
447.225

[ 闪点 ]:
334.8±31.5 °C

[ 精确质量 ]:
446.007233

[ LogP ]:
4.44

[ 外观性状 ]:
salt-free, lyophilized powder | white

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.722

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
0.25 M glycyl-glycine, pH 7.4: soluble5.0mg/mL, clear, colorless to slightly yellow

肌酸激酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
35079090

肌酸激酶制备

1.以兔肌为原料，经匀浆、热处理后由乙醇第一次分级，除去变性蛋白，经硫酸镁抽提后乙醇二次分级，重结晶得产品。

肌酸激酶文献

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

The DNA sequence and biology of human chromosome 19.

Nature 428(6982) , 529-35, (2004)

Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and dens...

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U. S. A. 105(31) , 10762-7, (2008)

The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all cellular material into two newly formed daug...

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