3-磷酸甘油酸激酶

3-磷酸甘油酸激酶用途

磷酸甘油酸激酶(PGK),即磷酸甘油酸酶,是一种常用于生化研究的糖酵解酶。磷酸甘油酸激酶可以催化磷酸基团从1,3-二磷酸甘油酸(1,3-BPG)向ADP的可逆转移,生成3-磷酸甘油酸酯(3-PG)和ATP。同时,它还可以参与糖异生,催化相反的反应产生1,3BPGA和ADP。磷酸甘油酸激酶参与能量代谢、与核酸的相互作用、肿瘤进展、细胞死亡和病毒复制以及其他相关过程[1]。

3-磷酸甘油酸激酶名称

[ CAS 号 ]:
9001-83-6

[ 中文名 ]:
磷酰甘油酸盐激酶

[ 英文名 ]:
Phosphoglycerate kinase

[中文别名 ]:

[英文别名 ]:

Histidine, β-alanyl-
MFCD00130301
3-PHOSPHOGLYCERIC PHOSPHOKINASE
N-(3-Aminopropanoyl)histidine
ATP: 3-PHOSPHO-D-GLYCERATE 1-PHOSPHOTRANSFERASE
EINECS 232-636-1
EC 2.7.2.3
b-Alanylhistidine
β-Alanylhistidine
carnosine

3-磷酸甘油酸激酶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 内分泌

研究领域 >> 感染

[参考文献]

[1]. Maura Rojas-Pirela, et al. Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea. Open Biol. 2020 Nov;10(11):200302.

3-磷酸甘油酸激酶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
656.2±55.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₄N₄O₃

[ 分子量 ]:
226.232

[ 闪点 ]:
350.7±31.5 °C

[ 精确质量 ]:
226.106583

[ LogP ]:
-2.17

[ 外观性状 ]:
悬浊液

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
2-8°C

3-磷酸甘油酸激酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

3-磷酸甘油酸激酶文献

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal. 2 , ra46, (2009)

Protein phosphorylation events during T cell receptor (TCR) signaling control the formation of complexes among proteins proximal to the TCR, the activation of kinase cascades, and the activation of tr...

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

The first identification of lysine malonylation substrates and its regulatory enzyme.

Mol. Cell. Proteomics 10(12) , M111.012658, (2011)

Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation, acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key role in the regu...

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