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吐温80

吐温80用途

Tween 80 是一种表面活性剂,可以减少细菌附着并抑制生物膜的形成。

吐温80名称

[ CAS 号 ]:
9005-65-6

[ 中文名 ]:
吐温80

[ 英文名 ]:
Tween 80

[中文别名 ]:

[英文别名 ]:

Bz-dCPhosphoramidite
DMT-dC(bz) amidite
SC-3-LY
Bz-dC Phosphoramidite
polyoxyethylene 20 sorbitan monooleate
polyoxyethylene sorbitan monooleate
polysceptroside
EINECS 500-019-9
polyoxyethylene sorbitol monooleate
MFCD00082107

吐温80生物活性

[ 描述 ]:

Tween 80 是一种表面活性剂,可以减少细菌附着并抑制生物膜的形成。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

生化试剂

研究领域 >> 其他

[体外研究]

吐温80是一种表面活性剂,它还可以减少细菌附着并抑制生物膜形成[1]。在体外使用1％吐温80可以实现高达100倍的溶解度增强[2]。

[参考文献]

[1]. Brandl MT, et al. Effect of the surfactant tween 80 on the detachment and dispersal of Salmonella enterica serovar Thompson single cells and aggregates from cilantro leaves as revealed by image analysis. Appl Environ Microbiol. 2014 Aug;80(16):5037-42.

[2]. Pan Y, et al. Pharmacokinetics study of ferulic acid in rats after oral administration of γ-oryzanol under combined use of Tween 80 by LC/MS/MS. Eur Rev Med Pharmacol Sci. 2014;18(2):143-50.

[相关活性小分子]

吐温80物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
695.8±55.0 °C at 760 mmHg

[ 熔点 ]:
-21ºC

[ 分子式 ]:
C₄₆H₅₂N₅O₈P

[ 分子量 ]:
833.907

[ 闪点 ]:
207.1±25.0 °C

[ 精确质量 ]:
833.355347

[ PSA ]:
133.14000

[ LogP ]:
9.39

[ 外观性状 ]:
淡黄色油性液体

[ 蒸汽压 ]:
0.0±5.0 mmHg at 25°C

[ 折射率 ]:
1.502

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
5-10 g/100 mL at 23 ºC

吐温80MSDS

详细MSDS(安全技术说明书)

吐温80毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG2932500

CHEMICAL NAME :: Sorbitan, monooleate polyoxyethylene deriv.

CAS REGISTRY NUMBER :: 9005-65-6

LAST UPDATED :: 199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6804 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Cardiac - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Cardiac - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 25 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 5800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 gm/kg/2W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2163 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - adrenal cortex tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 635 gm/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1270 gm/kg

SEX/DURATION :: female 84 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 uL/kg

SEX/DURATION :: lactating female 4 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Effects on Newborn - physical

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 20 ppm

REFERENCE :: ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark) V.2-5, 1972-75. Discontinued. Volume(issue)/page/year: 5,84,1975 *** REVIEWS *** TOXICOLOGY REVIEW ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 32,245,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80605 No. of Facilities: 1388 (estimated) No. of Industries: 18 No. of Occupations: 32 No. of Employees: 24861 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8582 No. of Facilities: 6365 (estimated) No. of Industries: 38 No. of Occupations: 70 No. of Employees: 162120 (estimated) No. of Female Employees: 112349 (estimated)

吐温80安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
22-36/37/38-37/38-41

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WG2934000

[ 海关编码 ]:
2932999099

吐温80上下游产品

吐温80上游产品

吐温80下游产品

吐温80制备

1. 将山梨醇加热减压蒸馏，收集60-85℃（8.0kPa）蒸出水分达到计算量，趁热出料，得失水山梨醇。将其与油酸酯化，得斯盘80。然后，将斯盘80与环氧乙烷在碱催化下缩聚，得到吐温80。

2. 将360kg司盘60加入不锈钢搅拌反应釜中，加热熔化后搅拌，再加入50%的氢氧化钾溶液8kg,密封反应釜，抽真空进行脱水和脱空气。当物料温度升高至110～120℃，釜上视镜的内表面上无水滴或水雾时，即完成脱水。再经数次充入干燥氮气置换空气后，停止抽真空，升温至140℃，开始通入环氧乙烷。控制反应温度为160～180℃，压力不超过0.2MPa。当通入的环氧乙烷接近800kg时，取样测反应物的浊点，当1%的活性物在10%的氯化钠溶液中的浊点达到58～62℃时，反应即达到终点。将产物冷却至80～90℃，搅拌下加入冰醋酸，调节pH值为5～7。然后在搅拌下，滴加双氧水12～15kg进行漂白，搅拌1h后，冷却，放料，可得成品1100kg。

3.将1 mol预热的斯盘8 0投入反应釜中,在搅拌下加入催化剂量的氢氧化钠,升温,并抽真空用氮气置换釜中空气,温度控制在1 3 0~1 4 0℃开始通入5 m o l环氧乙烷,反应温度维持在1 5 0~1 6 0℃。通完环氧乙烷后冷却,将料液打入中和釜用冰醋酸调酸值至2左右,再用双氧水脱色,最后脱水5 h,得成品。反应式如下:

吐温80海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吐温80文献

Comparing the xylose reductase/xylitol dehydrogenase and xylose isomerase pathways in arabinose and xylose fermenting Saccharomyces cerevisiae strains.

Biotechnol. Biofuels 1(1) , 16, (2008)

Ethanolic fermentation of lignocellulosic biomass is a sustainable option for the production of bioethanol. This process would greatly benefit from recombinant Saccharomyces cerevisiae strains also ab...

Chemical modification of reactive multilayered films fabricated from poly(2-alkenyl azlactone)s: design of surfaces that prevent or promote mammalian cell adhesion and bacterial biofilm growth.

Biomacromolecules 10(6) , 1564-74, (2009)

We report an approach to the design of reactive polymer films that can be functionalized post-fabrication to either prevent or promote the attachment and growth of cells. Our approach is based on the ...

Deformation of double emulsions under conditions of flow cytometry hydrodynamic focusing.

Lab Chip 15 , 4291-301, (2015)

Water-in-oil-in-water (w/o/w) microfluidics double emulsions offer a new route to compartmentalise reagents into isolated aqueous microenvironments while maintaining an aqueous carrier fluid phase; th...

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