S-腺苷-L-甲硫氨酸转移酶

S-腺苷-L-甲硫氨酸转移酶用途

儿茶酚O-甲基转移酶(COMT)是甲基从S-腺苷甲硫氨酸向多巴胺上的羟基的镁依赖性转移,将其转化为3-甲氧基酪胺。儿茶酚O-甲基转移酶在组织中有两种形式,可溶性形式(S-COMT)和膜结合形式(MB-COMT)。儿茶酚O-甲基转移酶用于调节大脑中的肾上腺素、去甲肾上腺素和多巴胺水平[1]。

S-腺苷-L-甲硫氨酸转移酶名称

[ CAS 号 ]:
9012-25-3

[ 中文名 ]:
S-腺苷-L-蛋氨酸

[ 英文名 ]:
catechol o-methyltransferase

[中文别名 ]:

儿茶酚氧位甲基转移酶

[英文别名 ]:

MFCD00081488
EINECS 232-727-6

S-腺苷-L-甲硫氨酸转移酶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Du X, et, al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14609-14.

S-腺苷-L-甲硫氨酸转移酶物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
771.4±40.0 °C at 760 mmHg

[ 分子式 ]:
C₃₈H₆₈O₇

[ 分子量 ]:
636.942

[ 闪点 ]:
227.5±20.8 °C

[ 精确质量 ]:
636.496521

[ LogP ]:
7.50

[ 外观性状 ]:
lyophilized powder

[ 蒸汽压 ]:
0.0±6.0 mmHg at 25°C

[ 折射率 ]:
1.507

[ 储存条件 ]:
−20°C

S-腺苷-L-甲硫氨酸转移酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

S-腺苷-L-甲硫氨酸转移酶文献

Initial characterization of the human central proteome.

BMC Syst. Biol. 5 , 17, (2011)

On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous...

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet. 36 , 40-5, (2004)

As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone...

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res. 14 , 2121-7, (2004)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for...

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