α类固醇脱氢酶

α类固醇脱氢酶用途

3α-羟基类固醇脱氢酶(3α-HSD)是一种由AKR1C4基因编码的酶,可以催化3-酮甾体转化为3α-羟化合物。3α-羟基类固醇脱氢酶在雄激素DHT的失活中起着重要作用,可将DHT转化为雄激素活性较弱的3α-雄甾二醇,可用于多毛症的研究[1]。

α类固醇脱氢酶名称

[ CAS 号 ]:
9028-56-2

[ 中文名 ]:
类固醇脱氢酶

[ 英文名 ]:
3alpha-hydroxysteroid dehydrogenase

[中文别名 ]:

[英文别名 ]:

ALPHA-HYDROXYSTEROID DEHYDROGENASE
3ALPHA-HYDROXYSTEROID: NAD[P]+ OXIDOREDUCTASE
EC 1.1.1.50
EC: 1.1.1.50
Dehydrogenase, 3alpha-hydroxy steroid

α类固醇脱氢酶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

[参考文献]

[1]. Anne Z Steiner, et al. 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. J Clin Endocrinol Metab. 2008 Apr;93(4):1298-303.

α类固醇脱氢酶物理化学性质

[ 外观性状 ]:
ammonium sulfate suspension

[ 储存条件 ]:
2-8°C

α类固醇脱氢酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

α类固醇脱氢酶文献

Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase.

Bioorg. Med. Chem. 16 , 1084-9, (2008)

Stereoselective reductive metabolism of various p-substituted acetophenone derivatives was studied using isolated rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD). Kinetic experiments were p...

Enzyme biosensor for androsterone based on 3α-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode.

Talanta 99 , 697-702, (2012)

A 3α-hydrosteroid biosensor for androsterone determination has been prepared by immobilizing the enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD) in a composite electrode platform constituted of a mixt...

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Biochem. Biophys. Res. Commun. 148(2) , 646-52, (1987)

Homogeneous 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) from rat liver cytosol displays 9, 11, and 15-hydroxyprostaglandin dehydrogenase activity. Using [14C]-PGF2 alpha as substrate the produc...

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