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4,4'-二羟基联苯

4,4'-二羟基联苯用途

4,4'-二羟基联苯是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

4,4'-二羟基联苯名称

[ CAS 号 ]:
92-88-6

[ 中文名 ]:
4,4'-二羟基联苯

[ 英文名 ]:
4,4'-Dihydroxybiphenyl

[中文别名 ]:

[英文别名 ]:

4,4'-Biphenyldiol
[1,1'-Biphenyl]-4,4'-diol
biphenyl-4,4'-diol
Antioxidant DOD
4,4'-Dioxydiphenyl
para,para'-Biphenol
EINECS 202-200-5
4,4'-Biphenol
4,4'-Diphenol
4,4'-dihydroxybiphenyl

4,4'-二羟基联苯生物活性

[ 描述 ]:

4,4'-二羟基联苯是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

4,4英寸-二羟基联苯用于制备塑料。用作实验室试剂和制备聚醚液晶的中间体。此外,它还用作橡胶和乳胶的抗氧化剂。除此之外,它还用于浅色橡胶制品、食品包装和医用乳胶制品。

4,4'-二羟基联苯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
355.2±17.0 °C at 760 mmHg

[ 熔点 ]:
280-282 °C(lit.)

[ 分子式 ]:
C₁₂H₁₀O₂

[ 分子量 ]:
186.21

[ 闪点 ]:
176.1±15.5 °C

[ 精确质量 ]:
186.068085

[ PSA ]:
40.46000

[ LogP ]:
2.42

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

[ 水溶解性 ]:
sparingly soluble

4,4'-二羟基联苯MSDS

4,4'-二羟基联苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV4725000

CHEMICAL NAME :: 4,4'-Biphenyldiol

CAS REGISTRY NUMBER :: 92-88-6

BEILSTEIN REFERENCE NO. :: 1908886

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H10-O2

MOLECULAR WEIGHT :: 186.22

WISWESSER LINE NOTATION :: QR DR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4920 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 208,61,1988

4,4'-二羟基联苯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R21;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DV4725000

[ 海关编码 ]:
29061900

4,4'-二羟基联苯合成路线

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4,4'-二羟基联苯制备

1.将硫酸加入反应釜，搅拌下升温至50℃加入联苯胺，搅拌溶解生成联苯胺硫酸盐，然后冷却至5℃以下，加入亚硝酸钠，使联苯胺硫酸盐发生重氮化，再在搅拌下，将重氮液加热至沸腾而水解，析出4，4′-二羟基联苯。重氮化需20h。水解完全需4h。水解液趁热过滤，然后经洗涤、干燥，再用升华法精制而得成品。

2..联苯胺盐重氮化法　将硫酸加入反应釜，搅拌下升温至50℃加胺，搅拌溶解生成联苯胺硫酸盐，然后冷却至5℃以下，加入亚硝酸钠，使联苯胺硫酸盐发生重氮化，再在搅拌下，将重氮液加热至沸腾而水解，析出4,4'-二羟基联苯。重氮化需20h。水解完全需4h。水解液趁热过滤，然后经洗涤、干燥，再用升华法精制而得成品。主反应如下：

①4,4'-二羟基联苯磺酸钠的制备　将30.8g（0.2mol）联苯加热至80℃，在80～100℃用平衡加料器一次性加入54.0mL质量分数为98%的浓硫酸，升温至160℃，恒温1h，冷却至室温，加入碎冰使产物刚好能完全溶解。将64.0gNaOH配制成质量分数为30%的水溶液，边搅拌边加入到磺化产物之中，立即有白色磺酸盐析出；中和至中性（最后10mL需小心加入），稍冷至40℃，滤出析出的固体，烘干得产品64.5g，收率90%。
②4,4'-二羟基联苯的制备　将10.7g（0.03mol）经过重结晶的4,4'-联苯二磺酸钠、13.5（0.24mol）氢氧化钾、31.5g水混合均匀，用热电偶控制温度为340℃，反应8h后自然冷却至室温。加入200mL水，加热使之溶解，趁热滤出不溶的杂质；在搅拌状态下向该溶液中滴加稀盐酸至pH值为4～5；滤出析出的产物，冷水洗涤2～3次，晾干或真空干燥得粉末状产物4.9g，产率88%。用犞（乙醇）∶犞（水）＝1∶1的溶剂重结晶得到无色片状晶体，熔点为274～275℃（从220℃左右开始升华）。

4,4'-二羟基联苯海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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