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盐酸苯氧沙星

盐酸苯氧沙星用途

盐酸苯诺沙坦是一种有效的α1肾上腺素受体拮抗剂,可用于研究厌食症[1]。

盐酸苯氧沙星名称

[ CAS 号 ]:
92642-97-2

[ 中文名 ]:
盐酸苯氧沙星

[ 英文名 ]:
BENOXATHIAN HCL

[英文别名 ]:

Benoxathian hydrochloride
Benoxathian HCl

盐酸苯氧沙星生物活性

[ 描述 ]:

盐酸苯诺沙坦是一种有效的α1肾上腺素受体拮抗剂,可用于研究厌食症[1]。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[ 靶点 ]

α1 Adrenoceptor[1]

[体内研究]

盐酸苯诺沙坦(10 nM；室旁核注射)完全逆转2.5、5.0或10.0 mg/kg苯丙醇胺(IP)诱导的大鼠厌食[1]。

[参考文献]

[1]. Wellman PJ, et al. Reversal of phenylpropanolamine anorexia in rats by the alpha-1 receptor antagonist benoxathian. Pharmacol Biochem Behav. 1991 Apr;38(4):905-8.

盐酸苯氧沙星物理化学性质

[ 沸点 ]:
500.7ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₄ClNO₄S

[ 分子量 ]:
397.91600

[ 闪点 ]:
256.6ºC

[ 精确质量 ]:
397.11100

[ PSA ]:
74.25000

[ LogP ]:
4.41840

[ 储存条件 ]:
室温

盐酸苯氧沙星MSDS

详细MSDS(安全技术说明书)

盐酸苯氧沙星安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

盐酸苯氧沙星文献

Liquid chromatography-quadrupole time-of-flight mass spectrometry for screening in vitro drug metabolites in humans: investigation on seven phenethylamine-based designer drugs.

J. Pharm. Biomed. Anal. 114 , 355-75, (2015)

Phenethylamine-based designer drugs are prevalent within the new psychoactive substance market. Characterisation of their metabolites is important in order to identify suitable biomarkers which can be...

α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism.

Exp. Cell Res. 317(16) , 2239-51, (2011)

Preliminary data showed that α1-adrenergic antagonists induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells. To test the hypothesis whether survival and ...

Activated endothelial cells limit inflammatory response, but increase chemoattractant potential and bacterial clearance by human monocytes.

Cell Biol. Int. 39 , 721-32, (2015)

Inflammation is the normal immune response of vascularized tissues to damage and bacterial products, for which leukocyte transendothelial migration (TEM) is critical. The effects of cell-to-cell conta...

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