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对羟基苯甲酸丙酯

对羟基苯甲酸丙酯用途

Propylparaben 是一种抗菌剂、防腐剂、调味剂。

对羟基苯甲酸丙酯名称

[ CAS 号 ]:
94-13-3

[ 中文名 ]:
尼泊金丙酯

[ 英文名 ]:
Propyl paraben

[中文别名 ]:

[英文别名 ]:

Propyl parahydroxybenzoate
Propyl-4-hydroxybenzoate
Mekkings P
4-hydroxybenzoic acid propyl ester
nipaginp
PROPYL PARASEPT
Nipasol M
Benzoic acid, p-hydroxy-, propyl ester
N-Propyl-p-hydroxybenzoate
Propyl chemosept

对羟基苯甲酸丙酯生物活性

[ 描述 ]:

Propylparaben 是一种抗菌剂、防腐剂、调味剂。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

天然产物 >> 其他

研究领域 >> 感染

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

对羟基苯甲酸丙酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
294.3±13.0 °C at 760 mmHg

[ 熔点 ]:
95-98 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂O₃

[ 分子量 ]:
180.201

[ 闪点 ]:
124.6±12.6 °C

[ 精确质量 ]:
180.078644

[ PSA ]:
46.53000

[ LogP ]:
2.93

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
库房低温,通风,干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

[ 水溶解性 ]:
<0.1 g/100 mL at 12 ºC

对羟基苯甲酸丙酯MSDS

对羟基苯甲酸丙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2800000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, propyl ester

CAS REGISTRY NUMBER :: 94-13-3

BEILSTEIN REFERENCE NO. :: 1103245

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H12-O3

MOLECULAR WEIGHT :: 180.22

WISWESSER LINE NOTATION :: QR DVO3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6332 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 28,463,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,135,1960

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 146,208,1929 *** REVIEWS *** TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,575,1954 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80496 No. of Facilities: 2827 (estimated) No. of Industries: 21 No. of Occupations: 36 No. of Employees: 48242 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80496 No. of Facilities: 13566 (estimated) No. of Industries: 86 No. of Occupations: 117 No. of Employees: 526606 (estimated) No. of Female Employees: 355310 (estimated)

对羟基苯甲酸丙酯安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
DH2800000

[ 海关编码 ]:
2918290000

对羟基苯甲酸丙酯合成路线

对羟基苯甲酸丙酯上下游产品

对羟基苯甲酸丙酯上游产品

对羟基苯甲酸丙酯下游产品

对羟基苯甲酸丙酯制备

1.由对羟基苯甲酸与正丙醇酯化而得。将对羟基苯甲酸和丙醇混合，加热使溶解，慢慢加入硫酸，继续加热回流8h后冷却，倒入4%碳酸钠溶液中析出结晶，过滤，水洗至中性即为粗品，再经乙醇重结晶而得成品。制备中，也可采用阳离子交换树脂代替硫酸催化剂。

2.由对羟基苯甲酸与正丙醇酯化，经脱色、重结晶制得。

对羟基苯甲酸丙酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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