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GSK1016790A

GSK1016790A用途

GSK101 (GSK1016790A)是一个新颖的TRPV4激活剂。

GSK1016790A名称

[ CAS 号 ]:
942206-85-1

[ 中文名 ]:
GSK1016790A

[ 英文名 ]:
GSK-1016790A

[英文别名 ]:

GSK1016790A

GSK1016790A生物活性

[ 描述 ]:

GSK1016790A是有效的瞬时受体电位香草酸4 (TRPV4) 激活剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 癌症

[参考文献]

[1]. Jin M et al. Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A. PLoS One, 2011 Feb 14;6(2):e16713.

[2]. MP Addison et al. NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2. Pharmacol Rep, 2016 Jun, 68(3):620-6.

[相关活性小分子]

辣椒碱 | 辣椒平 | 5-(N-乙基-N-异丙基)阿米洛利 | 氯化二亚苯基碘鎓 | 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 | HC-067047 | AMG9810 | SAR7334 | PF-4840154 | RN-1734 | AMG 517 | 3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺 | 冰素 | ML204

GSK1016790A物理化学性质

[ 分子式 ]:
C₂₈H₃₂Cl₂N₄O₆S₂

[ 分子量 ]:
655.61300

[ 精确质量 ]:
654.11400

[ PSA ]:
176.23000

[ LogP ]:
5.28510

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

GSK1016790AMSDS

详细MSDS(安全技术说明书)

GSK1016790A安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

GSK1016790A文献

Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(8) , R945-55, (2014)

Transient receptor potential vanilloid family type 4 (TRPV4) channels are expressed in central neuroendocrine neurons and have been shown to be polymodal in other systems. We previously reported that ...

Opposing actions of TRPV4 channel activation in the lung vasculature.

Respir. Physiol. Neurobiol. 219 , 43-50, (2015)

Transient receptor potential vanilloid 4 (TRPV4) calcium channels are known to promote endothelium-dependent relaxation of mouse mesenteric arteries but TRPV4's role in the pulmonary vasculature is un...

A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia.

Am. J. Med. Genet. A 167A , 2286-93, (2015)

Transient receptor potential cation channel, subfamily V, member 4 (TRPV4) is a polymodal modulated non-selective cation channel required for normal development and maintenance of bone and cartilage. ...

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